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HerbSprout Microbiome Blog -


Herbsprout is a webblog and podcast dedicated to sharing the health benefits of herbs, food, innovations related to our gut microbiome. Herbsprout seeks to bridge the vast chasm dividing the mainstream medical community, alternative medicine, and Asian medicine, especially of China (TCM), India (Ayurveda), and Japan (eJim & Kampo).

gut bacteria reduces productivity as we age

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According to a January 25, 2022 Medical News Today report, gut bacteria which produce a metabolite called urolithin A improves the overall efficiency of mitochondria, which prevent fatigue and helps maintain strength and endurance.

Part of the issue is that as we age, our cells progressively lose their capacity for “mitophagy”, which is the breakdown and recycling of faulty mitochondria, says David Marcinek, Ph.D., a professor of radiology at the University of Washington School of Medicine in Seattle. Professor Marcinek and his team are currently exploring clinical trials of Urolithin A supplements to determine efficacy for the aging.
Would you use Urolithin A supplements if it were safe and available?

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Gut bacterial chemical promotes obesity

Delta-valerobetaine, a bacterial metabolite is said to provide a starting point to understand our gut microbiome as a link between diet and body composition, according to Dean Jones, professor of medicine at Emory University School of Medicine and co-senior author of the paper in a January 31, 2022 article. Delta-valerobetaine was identified by comparing the livers of conventionally housed mice with those in germ-free mice.

Researchers found that the delta-valerobetaine decreases the liver’s ability to burn fat during fasting periods. The molecule was first identified by Ken Liu, a former molecular and systems pharmacology graduate student who is the first author of the paper.

Certain varieties of bacteria are believed to produce more delta-valerobetaine than others. The article says the Cleveland Clinic confirmed that TMAO (trimethylamine N-oxide) of which Delta-valerobetaine is a precursor, is associated with cardiovascular disease.

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