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Herbsprout is a webblog and podcast dedicated to sharing the health benefits of herbs, food, innovations related to our gut microbiome. Herbsprout seeks to bridge the vast chasm dividing the mainstream medical community and alternative medicine.

Looking for specific microbes helps identify cancer; aids in early treatments

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Subhajyoti De, associate professor of cancer systems biology at Rutgers Cancer Institute of New Jersey together with RWJBarnabas Health, found that microorganisms may be new targets for earlier diagnosis or treatment of pancreatic cancer (1).

According to the October 10 2022 Rutgers University press release, they were able to identify tumor-associated microbes and measure the activity of the host cells at the same time. They examined the microbiome of pancreatic tumors and identified particular microorganisms that are associated with inflammation and poor survival (2).

Short of two weeks earlier, research by Lian Narunsky Haziza, a cancer biologist at the Weizmann Institute of Science in Israel, found that tumors contain millions of microbes and fungi, representing dozens of species, according to a September 29 2022 New York Times article (2).

So-called tumor microbiome is proving so distinctive in each type of cancer that some scientists hope to find early signs of hidden tumors by measuring the microbial DNA they shed into the blood, says the study led by Dr. Haziza.


#bacteria #cancercells #guthealth #gutmicrobiome #healthinnovation #microbiome #tumor

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Cayenne pepper helps to diversify microbiome community

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On April 19 2022 Mind Body Green reported a study that found "that capsaicin (in cayenne pepper) alters the gut microbial community structure by increasing the diversity of the community." Capsaicin is an antioxidant said to aid in proper digestion, with anti-inflammatory effects. Researchers used the in vitro model to conduct their research.

Capsaicin stimulates the nerves in your stomach and us said to help to increase the production of digestive fluid. According to WebMD, it sends enzymes to the stomach to aid in digestion, and protectshe the stomach from infections.
#bacteria #datascience #gutmicrobiome #health #healthinnovation #wellness

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Sugar diets are not healthy especially for IBD patients; 砂糖食は特に炎症性腸疾患IBDの患者にとっては健康的ではありません

Sugar diets are...
On October 28 2020 Inverse reported the impact of sugar consumption in mice led by co-author, Hasan Zaki, a researcher at the University of Texas Southwestern Medical Center. He and his team studied the effects of different types of sugars on gut microbiome by testing inflammatory responses on gut microbiota in mice.

They tested the impact of glucose, sucrose, and fructose on inflammatory bowel diseases (IBD) such as Crohn’s disease and ulcerative colitis. The mice were fed high levels of these sugars for one to five weeks.

Mice that were given these high sugar diets suffered from aggressive colon inflammation with severe diarrhea and a rapid loss of nearly 20 percent of their body weight. The sugar was fed to a particular gut bacteria called Akkermansia muciniphila, known to degrade mucus in the gut lining.

Researchers also transferred the gut microbiota of sugar-fed mice into healthy mice. The result also exacerbated healthy mice, who received the gut microbiota transferred from the sugar fed mice.

2020年10月28日、共著者に指導でテキサス大学南西医療センターの研究者のHasan Zakiがマウスの砂糖消費の影響について報告しました。




See the following articles on IBD for additional information:
#IBD #ai #bacteria #cardiovasculardisease #datascience #gutmicrobiome #health #healthinnovation #healthtech #obesity #wellness

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Microbiome Health Chart, October 2020 (click on chart to ZOOM IN)

This chart shows connections between our gut microbiome and various ailments or diseases, and offers food, herbal remedies, or supplements which may give relief to those ailments by positively impacting the microbiome.
This is not medical advice, so consult your doctor before making any health related decisions. Copyright (C) MobileZinger LLC.
#ai #artificialintelligence #bacteria #datascience #diet #gutmicrobiome #health #healthinnovation #healthtech #herbalmedicine #herbs #machinelearning #mindbody #plantnutrition #spices

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2 short chain fatty acids in the gut tied to breast cancer treatment efficacy

October is Breast Cancer Awa... October is Breast Cancer Awareness Month; source:
Just as we have reported last week about how the presence of butyrate supports a healthy gut, on the other hand, it can be detrimental to breast cancer chemotherapy. According to a September 17 2020 report in the American Journal of Managed Care (AJMC), 2 short chain fatty acids (SCFAs), propionate and butyrate, have been identified as tied to the efficacy of breast cancer chemotherapy (1). The study was conducted in Scotland led by Kirsty Ross, MBChB, MSc, a specialist registrar in medical oncology at the Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom. The Beatson West Cancer Centre studied 21 patients with early-stage breast cancer.

The SCFAs were shown to be lower in the gut bacteria of patients achieving pathological complete response (pCR) compared with those not achieving pCR after surgery. According to Ross and her colleagues, they "dampen down the immune system’s ability to target cancer cells", as quoted in the AJMC article (1).

This points back to the fact that when it comes to personal health, it is very personal, and what is healthy for one person is not necessarily healthy for another person. As Herbsprout article quoted Viome CEO Naveen Jain, "one man's food is another man's poison." (2)


#ai #bacteria #breastcancer #cancer #cardiovasculardisease #datascience #gutmicrobiome #health #healthinnovation #healthtech #obesity

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The health benefits of butter

The health benefits of butter
One common misconception is that butter is not healthy for you because it is fattening. It is true. It is fattening, but in a good way; it contains good fat. Butter is a good source of healthy fat, omega-3 fatty acids, particularly unsaturated, organic butter. It is the best, richest dietary source of a short chain fatty acid (SCFA) called butyrate.

The microbiome in our gut are known to metabolize acetate, propionate, and butyrate (at 60%, 25%, and 15% respectively), according to Dr. Deanna Minich (1). Butyrate is rich source of energy for the cells in our gut.

Butyrate is the energy source for cells that line the wall of our gut and helps prevent diarrhea and other digestive health issues. Beyond that, it plays a key role as an anti-inflammatory, gene regulation, and maintaining a balanced immune system.

In addition to butyrate, Butter is an excellent source of vitamin A, Vitamin E, and another fat called conjugated linoleic acid (CLA), which is also known to be an anti-inflammatory and provide immune support (2).


#ai #bacteria #cardiovasculardisease #datascience #gutmicrobiome #health #healthinnovation #healthtech #obesity

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New discovery about how bacteria adheres to our gut's cell walls

New discovery about how bact...
Researchers at the University of Basel and ETH Zurich have found a new mechanism by which bacteria adhere to cellulose fibers on the cell walls of the human gut, according to an August 28 2020 article in Phys.Org.

The significance of understanding this is it helps us understand an important part of how our gut microbiome influences our health. Professor Michael Nash from the University of Basel and ETH Zurich studied combinations of "single-molecule atomic force microscopy, single-molecule fluorescence and molecular dynamics simulations", according to the report.

Researchers believe there is a dual binding mode, one significantly stronger than the other. The bacteria is believed to control the binding mode preference by modifying the proteins and the adherence strength. "This would allow switching from a low to high adhesion state depending on the environment," according to Nash. Learning this process and how it works may help scientists employ bacteria that adhere to certain disease targets, at the higher adhesion rate.
#ai #bacteria #datascience #gutmicrobiome #health #healthinnovation #healthtech #longevity #microbiome #nutrition #wellness

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How gut bacteria can enhance cancer treatment

The journal Science and an August 13 2020 article by The New Atlas describe how certain species of gut bacteria can improve cancer immunotherapy efficacy. The results are based on a study of mice and shows a new bacteria metabolite-immune pathway.

A study led by principle investigator Kathy McCoy, from the University of Calgary, isolated three particular bacterial species associated with positive immunotherapy. These were Bifidobacterium pseudolongum, Lactobacillus johnsonii and Olsenella.

The study of four mice also found that bacterial metabolite inosine plays a role in activating anti-tumor T-cells.

#ai #alternativemedicine #anticancer #bacteria #datascience #gutmicrobiome #health #healthinnovation #healthtech #herbalmedicine #herbs #integrativemedicine #plantnutrition

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Probiotics and fermented foods from the soil to the dinner table; quality matters

Probiotics and fermented foods... Kimchi and sauerkraut are am... Kimchi and sauerkraut are among the popular fermented foods today. Source:
Naturopathic Doctor Ningma Talib is quoted in an August 05 2020 article that "probiotics are great for most people." . . . "More than 70 percent of your immune system is in your gut,” she says. “Supporting your gut is supporting your immune function.” (1). Dr. Talib identified high quality lactobacillus and bifidobacteria DDS- 1 strains as among the most well studied and most important for your health.

Fermented foods have been around for a very long time. An August 11 2020 article in Refinery 29 said as early as 7000 BC, ancient Chinese consumed a fermented beverage called Kiu. Around 3500 BC there’s evidence of the ancient Egyptian practice of using yeast to leaven bread. By 2000 BC, across China, the fermentation of vegetables (kimchi) and home-brewed tea (kombucha) was a widespread practice (2). Germany and Russia followed in later years with sauerkraut and pickles, respectively.

In China, Japan, and Korea miso soup, tofu, and kimchi remain popular dishes today. Refinery 29 reported that fermented foods saw an 140% increase in popularity on American restaurant menus in 2018. It was based on a survey by restaurant management software company, Upserve. Kombucha grossed 1.67 billion dollars globally in 2019 (2).

Fermented foods waste is also known to have health benefits. Soil experts and farmers in Japan found that soil fertilized with compost made from fermented food waste yielded hardy, disease-resistant vegetables (3). So even at the pre-food soil level where food production begins, microbes are important. Japanese agronomist Yoshida Toshimichi states that "the repeated use of agrochemicals can upset the microbiota in the soil, which leaves plants susceptible to disease and insect pests."

Yoshida refers to the three dietary pillars of a strong immune system which are the elements of the traditional Japanese diet. These are fermented foods, high-fiber organic vegetables, and marine and soy products rich in minerals and micronutrient, he adds (3).


For more information on probiotics, see
a. ; and
b. Risks and benefits-
#ai #bacteria #datascience #gutmicrobiome #health #healthinnovation #healthtech #longevity #microbiome #nutrition #wellness

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Traditional Japanese diet incorporates organics and "kin", or microorganisms

Traditional Japanese diet incor...
Yoshida Toshimichi, a devout believer in the power of microbes, has been a leading advocate of schools and daycare centers growing their own organic vegetables. In his Nagasaki Prefecture, he has been a leading advocate of traditional Japanese diet, incorporating "kinchan" or friendly microorganisms into farming and diet. It includes incorporating these vegetables into school lunches along with fermented foods and dried fish.

The three "pillars" of this healthy Japanese diet are "fermented foods, high-fiber organic vegetables, and marine and soy products rich in minerals and micronutrients", according to Yoshida in a May 11, 2020 article (1).

One such school is Mami Nursery School which after implementing Yoshida's plan, saw a major drop in school absences due to illness had dropped from an average of 5.4 days to 0.6 days per year. The key is friendly microorganisms, a lesson Yoshida learned in the context of soil improvement as a soil improvement specialist for the Nagasaki Prefecture government. Microorganisms are supported by pesticide free compost made from fermented food waste yielded hardy, disease-resistant vegetables.

#ai #bacteria #datascience #gutmicrobiome #health #healthinnovation #healthtech #obesity

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