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“WHERE THINGS SO SMALL CAN HAVE A MASSIVE IMPACT ON YOUR HEALTH.”
Herbsprout is a webblog and podcast dedicated to sharing the health benefits of herbs, food, innovations related to our gut microbiome. Herbsprout seeks to bridge the vast chasm dividing the mainstream medical community and alternative medicine.

Adaptive Biotech gets creative with financing

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A worthwhile digression from Herbsprout’s standard health topics, Seattle-based biotech Adaptive Biotechnologies Corp. (Nasdaq: ADPT) came up with up to $250 million in innovative/ creative financing during the current economic downturn. The deal mix of business development revenue share with financing.

According to a September 14 2022 Puget Sound Business Journal report, the company inked a royalty financing agreement with health care investment firm OrbiMed. Adaptive is developing an immune system platform to build a data-driven, “clinical-product development engine”. With the immune system as the “source code”, Adaptive says it can develop diagnostics and therapeutics for almost any disease, according to the company.

Through the agreement, Adaptive will receive an initial $125 million in exchange for OrbiMed receiving 5% of Adaptive's revenue. Adaptive can receive an additional $75 million for 8% of its revenue and another $50 million, earmarked for potential merger and acquisition deals, for 10%.

"This was a really nice creative structure because for us, we didn't want to raise equity capital and dilute the shareholder base when our stock is trading significantly below historical levels," said Chad Robins, co-founder and CEO of Adaptive is quoted Puget Sound Business Journal. “Debt will have a balloon payment or an amortization where if for any reason the markets aren't there and you can't recapitalize or you can't repay that debt, that provides a lot of risk to a company."

Adaptive will have to pay OrbiMed back 1.65 times whatever it takes, but the rate decreases if Adaptive can pay the firm back in 18 or 24 months, Robins said. He added that although there is a $50 million tranche reserved for M&A, Adaptive isn't targeting anything specific right now. According to Robins, the company will lay out a path to profitability in its third quarter earnings, and this money will help Adaptive reach that goal without having to raise equity capital.

https://www.bizjournals.com/seattle/inno/stories/fundings/2022/09/14/adaptive-royalty-financing-agreement-orbimed.html

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Sleep Apnea underdiagnosed in connection to cardiovascular diseases

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source: sleep apnea occurs in... source: sleep apnea occurs in 40% of cardiovascular disease patients.
Obstructive sleep apnea (OSA) is one of the most common and serious sleep-related breathing disorders with a strong connection to patients with cardiovascular (CV) diseases.

Despite its prevalence, OSA is often underdiagnosed and untreated, even though it can increase risk of heart failure, arrhythmias, hypertension, and coronary artery disease, according to an August 11 2022 report by Handawi journal. The report claims that sleep apnea occurs in more than 40% of CV patients.

In addition to CV diseases, sleep apnea can result in repetitive upper airway collapse during sleep and insufficient oxygen.

https://www.hindawi.com/journals/cdtp/2022/6006127/

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treating depression by supporting our gut microbiome

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source: dreamstime source: dreamstime
The gut microbiome can be a promising approach for the management of depression. A September 7, 2022 Science Direct report suggest that the gut microbiota control the host epigenetic machinery in depression.

Gut dysbiosis causes negative epigenetic modifications via mechanisms like histone acetylation, DNA methylation and non-coding RNA mediated gene inhibition.

The diet and dietary metabolites like kynurenine, tryptophan, and propionic acid also greatly influence the microbiome composition and the physiological activities.

Science Direct point out that stress is one of the important risk factors for depression that results from chronic or early life stress, in the range of 37% to 48% showing a strong relation between family history and depression.

https://www.sciencedirect.com/science/article/abs/pii/S0166432822003497

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“Live Long and Prosper” with ketones & polyphenols

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source: dreamstime source: dreamstime
Distinguished doctor and medical researcher Dr. Steve Gundry says polyphenols aid in everything from heart health to gut health and weight loss. Why? Based on his research, Dr. Gundry discovered these polyhenols facilitate caloric bypass, enabling the mitochondria in our body to ignore excessive amounts of food, and bypass converting them into stored fats (1).

More than 8,000 polyphenols are out there, and they are divided into four main categories: flavonoids, stilbenes, lignans, and phenolic acids, according to a May 24, 2022 Wellandgood.com article (2).

Ketones created by our liver are even more effective than the polyphenol foods, in fact the most effective at signaling caloric bypass, but helps all your cells work better, according to the National Institute of Aging.

Dr. Gundry discovered medium chain triglycerides (MCT) naturally found in certain foods, can never be converted to fats and can only be converted to ketones. Both Columbia and McGill Universities confirmed studies that individuals who consume increasing amounts ketones showed significant decreases in body fat and weight. He found that communities that consume large amounts of — goat cheese sheeps milk, acacia, and coconut oil — each of which are among the largest sources of MCTs, are also among the longest living communities in the world (1).

Top sources of MCTs are coconut and coconut products - coconut oil, coconut butter and full fat coconut milk; palm kernel oil; and in lesser amounts- butter, milk, yogurt and cheese 3).

Top sources of polyphenols include Herbs and Spices such as ginger and turmeric, Cocoa, and berries such as blackberries, blueberries, and strawberries (2).

1) https://fb.watch/feicm0Zfwq/

2) https://www.wellandgood.com/polyphenols/#main-content

3) https://www.healthline.com/nutrition/mct-oil-101

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Gut bacteria that regulates cholesterol

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Gut bacteria that regulates cho...
A subset of bacteria called Bacteroides help to regulate cholesterol levels in the blood by producing cholesterol sulfate, according to postdoctoral researchers Henry Le and Ming-Ting Lee at the College of Agriculture and Life Sciences, co-first authors of the study (1).

Though more study is needed, early clues reveal cholesterol sulfate acts as a signaling molecule for a slew of biological pathways, according to a study published August 18 in Nature Microbiology and reported by Phys.org (1).

National Institute of Health says cholesterol sulfate is metabolized in different pathways. While it’s function of remains an enigma, cholesterol sulfate has emerged as a regulatory molecule, and serves an important stabilizing role (2).

1) https://phys.org/news/2022-08-gut-bacteria-cholesterol.amp

2) https://pubmed.ncbi.nlm.nih.gov/12730293/

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Microbe found to generate electricity

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source: freeimages source: freeimages
A sediment organism Geobacter sulfurreducens, first found along the Potomac River, has been discovered to generate an electrical charge, according to a February 2020 article in BigThink.

The microbe a member of the Geobacter genus, a group known as “electrigens” for their known ability to generate an electrical charge. “It was UMass Amherst microbiologist Derek Lovley who found and wrote about the microbe in the late 80s,” according to Big Think.

He found that the microbe produces electrically conductive protein nanowires, and his lab recently developed a new Geobacter strain that could produce them more rapidly and inexpensively. Lovely worked together with electrical engineer Jun Yao, also of UMass Amherst, to create a device they call “ air-gen”, creating “electricity out of thin air.” The Air-gen generates clean energy 24/7. “It’s the most amazing and exciting application of protein nanowires yet,” he’s quoted saying in BigThink.

https://bigthink.com/the-present/air-gen/

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Stool Bank for fecal transplant?

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image source: dreamstime.com image source: dreamstime.com
Fecal transplants don’t work from one person to another. But what about transplants of your younger self?

Researchers at Harvard Medical School and Brigham and Women’s Hospital claim it’s a good idea for people to bank their stool samples when they’re young and healthy to rejuvenate their gut microbiome, according to a June 30 2022 article in The Scientist (1). Dr. Scott Weiss and Yang-Yu Liu propose this stool bank for fecal transplant(s) for use later in life.

As scientists discover the importance of personalized medicine as the most effective approach to addressing a person’s individually unique health care needs, these researchers and others believe the key to its efficacy lies in a person’s past.

Already, a company in Singapore is thinking along the same lines. Cord life is the first company to work with the Asian Microbiome Library in Singapore to collect “precision” databank of stool samples (2).

1) https://www.the-scientist.com/news-opinion/banking-previous-poos-could-a-transplant-of-feces-from-your-past-heal-you-70180

2) https://thehomeground.asia/destinations/singapore/faecal-attraction-first-southeast-asia-poo-bank-set-up-in-singapore/

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Lactobacillus helps reduce depression

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Nuts about walnuts? It’s a good thing

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Nuts about waln...
Did you notice walnuts look like the brain? That’s because they’re good for the brain and not because they have the physical characteristics of a human brain but because they have the most omega-3 fatty acids of all the nuts, according to Facty.

But that’s not it. Walnuts have more good fatty acids, for heart health such as monounsaturated fatty acids. Walnuts contain healthy fatty acids like oleic acid and linoleic acid which can aide in reducing bad LDL cholesterol and increasing good HDL (high density lipoproteins) cholesterol; “the good cholesterol “ which removes harmful LDL cholesterol, as explained by Webmd (2).

https://facty.com/food/nutrition/the-delicious-health-benefits-of-walnuts/

2. https://www.webmd.com/cholesterol-management/guide/hdl-cholesterol-the-good-cholesterol

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Human microbiome market to become $1.37 billion by 2090

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Taking a break from science, what about the economics of our gut microbiome? According to a Digital Journal article reporting on MarketsandMarkets™, the global human microbiome market is projected to reach USD 1.37 billion by 2029 from USD 269 million in 2023, at a CAGR of 31.1% from 2023 to 2029.

The report says the growth is largely due to growth in gut microbiome treatment and drug development. Digital Journal reports that the Asia Pacific region is the fastest-growing region of human microbiome research spending market from 2023 to 2029.

https://www.digitaljournal.com/pr/human-microbiome-market-worth-1370-million-by-2029-global-trends-share-and-leading-key-players

Download PDF Brochure: https://www.marketsandmarkets.com/pdfdownloadNew.asp?id=37621904

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