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“WHERE THINGS SO SMALL CAN HAVE A MASSIVE IMPACT ON YOUR HEALTH.”
Herbsprout is a webblog and podcast dedicated to sharing the health benefits of herbs, food, innovations related to our gut microbiome. Herbsprout seeks to bridge the vast chasm dividing the mainstream medical community and alternative medicine.

humans and pets exposed to each other’s gut microbiome show improvements to lifelong health

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humans and pets...
In a brand new area of research, people exposed to more furry pets and green space early in life have a lower risk of immune and allergic conditions later, according to Curtis Huttenhower, professor of computational biology and bioinformatics at Harvard T.H. Chan School of Public Health in his June 29, 2023 interview. He believes some of those effects are due to the microbiome from their pets. Likewise, pets too can benefit from exposure to the human gut microbiome, adds Huttenhower.

In partnership with the Pet Nutrition Center, because pets maintain consistent food consumption, the Center’s staff along with robotics track the specific types and amounts of food consumed by each individual animal, which includes a consistent diet compared to humans.

Huttenhower explains how the degree to which high-fiber diets help prevent inflammation depends on which gut microbes people have, which is why people respond to the same diet differently. “We all carry vastly different bugs in our microbiomes,” he adds.

The interchange of pet and human microbes presents the opportunity to acquire the “right” microbes at the “right” times leading to better lifelong health.

https://www.hsph.harvard.edu/news/features/gut-microbiome-of-pets-reveals-insights-for-human-health-curtis-huttenhower/

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Machine learning of microbiome used to predict cancer

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Machine learning of microbiom...
Technology advances in DNA sequencing and more sophisticated data-analytics tools has led to extensive research on the relationship between the microbiome and diseases. Researchers are developing a machine learning-based approach to distinguish the type of cancer by analyzing the tissue-specific microbial information, according to the July 21, 2023 issue of Nature.com (1).

Random Forest models of five types of cancers from the Cancer Microbiome Atlas database, achieved promising performances when predicting head and neck, stomach, and colon cancer cases, with the latter showing 90% accuracy across the different studies conducted, says the Nature article. The random forest method forms multiple decision trees in machine learning by regression classification task outputs (2).

This research shows the potential of adopting machine learning techniques in predicting disease and cancer.

1. https://www.nature.com/articles/s41598-023-38670-0

2. https://en.m.wikipedia.org/wiki/Random_forest

 

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腸を元気にする 6 つのハーブ; 6 herbs that heal the gut

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Dr. Nicole Apelian Dr. Nicole Apelian Lion’s mane mus... Lion’s mane mushroom

The following is part two by guest author Dr. Nicole Apelian. She was among the first women selected for the History Channel’s hit TV show “Alone”. She has B.S and M.S. degrees in Biology from McGill University in Canada and the University of Oregon. She earned her Doctorate through Prescott College.

腸を元気にする 6 つのハーブ

以下は、ゲスト著者であるニコールアペリアン博士によるパート 2 です。彼女は、ヒ ストリーチャンネルの人気テレビ番組「アローン」に選ばれた最初の女性の一人でし た。 彼女は、カナダのマギル大学およびオレゴン大学で生物学の学位を取得し、学士号と修 士号を持っています。彼女はプレスコット大学で博士号を取得しました。
私は、腸を癒し、健康な微生物叢を促進する 霊芝・ライオンのたてがみ・七面鳥の尾 の薬用キノコ・オオバコ・アスリッパリーニレ・マシュマロ、6 つの特別なハーブを使 用しています。この植物は、炎症を軽減し、重要なプレバイオティクスを提供し、腸の 再生と治癒を可能にする保護膜を腸内に形成するのに役立ちます。追加の利点は、以下 で説明します。

霊芝(Ganoderma lucidum)
霊芝は、炎症の増加・ホルモンの不均衡・高コルチゾール、疲労などのストレスによる 悪影響に対して身体を強化する優れたアダプトゲンハーブです。ストレスが炎症を引き 起こす可能性があるため、霊芝は 多発性硬化病の場合に特に重要です。また霊芝も若 返りの睡眠を促し、副腎の健康を促進し、健康な免疫反応をサポートします。さらに、 神経保護作用があり、アレルギーを鎮め、抗ウイルス作用もあります。
ライオンのたてがみ (Hericium erinaceus)

ライオンのたてがみキノコは、神経系を強化し、腸の炎症に対処するため、多発性硬化 症を管理するためのもう一つの優れた漢方薬です。また、ミエリン鞘として知られる神 経線維を取り囲む保護的な脂肪コーティングの修復に必要な神経成長因子の促進にも役 立ちます。多発性硬化症の患者の場合、ミエリン鞘は重度の損傷を受けていることがよ くあります。このタンパク質は、学習・記憶・集中力に関与するニューロンを維持しま す。 研究により、ライオンのたてがみは認知機能も改善する効果もあることが証明さ れています。
七面鳥の尾 (トラメテス癜風)
もう一つ抗炎症作用のある薬用キノコは七面鳥の尾です。また、免疫システムの活性が 過剰になったり、活性が低下したりしないように調節するにも役立ち、自己免疫を管理 するための優れた漢方薬になります。 さらに、この印象的なキノコは優れたプレバイオティクスでもあり、カンジダと闘い、 小腸細菌の異常増殖 (SIBO) に対処します。

冬虫夏草 (Cordyceps militaris)
私は多発性硬化症を管理するために、毎日冬虫夏草の抽出物も使用しています。霊芝と
同様に、冬虫夏草は何世紀にもわたって伝統的な中国医学で使用されていました。冬虫
夏草は多発性硬化症患者にとって重要な考慮事項である神経細胞死を減らす神経保護特
性があることが知られています。このユニークなキノコは抗炎症作用があり、エネルギ
ーの改善に役立ちます。
また冬虫夏草は、抗菌性・抗バクテリア・抗ウイルス・抗真菌剤、抗原虫作用もあり、
腸の健康状態不良に対処するのに役立ちます。冬虫夏草は抗がん作用があり、血糖値も
調節する効果があります。最後に、オオバコ・アスリッパリーニレ・マシュマロの根が
炎症を鎮め、粘膜を落ち着かせ、腸の再生を助ける保護層を形成します。私がこの植物
はリーキーガットの治癒に不可欠であることがわかりました。
 天然ハーブと治療法についてさらに詳しく知りたい場合は、ニコール・アペリアン博士
 の著書『The Lost Book of Herbal Remedies: The Healing Power of Plant
 Medicine』をここから入手できます。
 割引料金で購入するには、チェックアウト時にクーポン WELCOME10 を使用し、最初の 注文から 10% オフにしてください。ニコールが日常的に多発性硬化症をどのように管
 理しているかについては、彼女の詳細ブログをお読みください。 ありがとう!
 • 霊芝は血管拡張作用があるため、出血性疾患のある方や手術前の使用は禁忌で す。
 ** Mase G. (2012)。 薬用キノコ: 主要な種の簡単な歴史と概要。2016 年 8 月
27 日に http://www.vtherbcenter.org/wp-
  content/uploads/2012/04/Medicinal-Mushrooms.pdf
   より取得する。
 • この記事の内容は情報提供のみを目的とし、医学的アドバイスを構成するもので
 はなく、診断や治療の代替を意図したものではないことにご注意ください。病状
に関する質問がある場合は、必ず資格のある医療提供者のアドバイスを求めてく
 ださい。この Website を読んだことを理由にして、専門の医学的アドバイスを
 無視したり、アドバイスを求めるのを遅らせたりしないでください。医療上の緊
 急事態が発生した場合は、直ちに医師または 911 に電話してください。 この
 Website が提供する情報を信頼する場合は、お客様ご自身の責任で行ってくださ
い。
 • ニコール・アペリアン博士は、薬草医・母親・サバイバルスキルのインストラク
 ター・人類学者・生物学者です。彼女はカナダのマギル大学およびオレゴン大学
で生物学の学位を取得し、学士号と修士号を持っています。彼女はボツワナで人
類学者および民族植物学者として働きながらプレスコット大学で博士号を取得し
 ました。

 彼女は、今も狩猟採集民として暮らしている最後の先住民族のひとつであるカラ
 ハリ砂漠のサン・ブッシュマンたちと一緒に自然の中で何年も暮らしてきまし
た。
 部族内で強い関係を現像することで、ニコールは現在実践し教えている治療法や
 スキルの多くを学び、非営利団体「The Origins Project」を通じてサン族との
 活動を続けています。
 2000 年に多発性硬化症と予期せぬ診断を受け、ニコールは自分の研究スキルを
 自分自身の健康に応用することになりました。彼女は、深い自然とのつながりや
 感謝の習慣など、健康的な生活戦略に焦点を当てました。ライフスタイルを変
 え、心と体の深いつながりを認識し、独自の治療法を作成して使用することによ
 って、ニコールは寝たきりから完全に生き、生存から繁栄へと成長しました。
 彼女は、苦しんでいるたくさんの人々が自分自身の治療法を見つける必要がある
 と信じています。
 これが彼女の人生の使命となり、著書『The Lost Book of Herbal Remedies:
 The Healing Power of Plant Medicine』を執筆する主な理由となった。その中
 に彼女は 28 年以上にわたる植物の知識と、湿布・チンキ剤・煎じ薬・軟膏・注
 入油、その他のハーブ療法を自分で作った直接の経験を注ぎ込みました。
 2015 年、彼女はヒストリー チャンネルの人気テレビ番組「アローン」に史上初 めて選ばれた女性の一人でした。多発性硬化症を患っていたにも関わらず、彼女 は狩猟用ナイフとそこで見つけた野生の食べ物と薬だけを持って、バンクーバー
 島の人里離れた地域で 57 日間連続で一人で生き続けた。
 ニコール・アペリアン博士について詳しくは、こちらをご覧ください。
https://nicoleapelian.com/. https://www.instagram.com/ nicole_apelian/https://www.facebook.com/nicoleapelian survival/


I use six specific herbs that heal the gut and promote a healthy microbiome: reishi, lion’s mane, and turkey tail medicinal mushrooms, along with plantain, slippery elm, and marshmallow. These botanicals help to calm inflammation, provide important prebiotics, and create a protective coating in the gut that allows it to regenerate and heal. They also have additional benefits, which we will explore below.

Reishi (Ganoderma lucidum)
(Link for reishi photo: https://nicolesapothecary.com/products/reishi-mushroom-tincture)
Reishi mushroom is an outstanding adaptogenic herb that strengthens the body against the negative effects of stress — such as increased inflammation, hormonal imbalance, high cortisol, and fatigue. This is particularly important if you have MS because stress can cause a flare. Reishi also encourages rejuvenating sleep, promotes adrenal health, and supports a healthy immune response. Moreover, it is neuroprotective, calms allergies, and is antiviral.

Lion’s Mane (Hericium erinaceus) (Link for lion’s mane photo:
https://nicolesapothecary.com/products/lions-mane-mushroom-tincture)
Lion’s mane mushroom is another impressive herbal medicine for managing MS as it fortifies the nervous system and addresses gut inflammation. It also helps to encourage Nerve Growth Factor (NGF), which is necessary for the repair of the protective, fatty coating surrounding nerve fibers known as the myelin sheath. For those with MS, the myelin sheath is often severely damaged. This protein maintains the neurons that are involved in learning, memory, and focus. Research has
established that lion’s mane also improves cognitive function.

Turkey Tail (Trametes versicolor)
(Link for turkey tail photo: https://nicolesapothecary.com/products/turkey-tail-mushroom-tincture)
Another anti-inflammatory medicinal mushroom is turkey tail. It also helps to modulate the immune system so that it is not over or under active, making it an excellent herbal remedy for managing autoimmunity. Turkey tail is exceptional for healing leaky gut, chronic fatigue syndrome, and treats a range of bacterial and viral infections as well. What’s more, this impressive mushroom is also an outstanding prebiotic, combats candida, and addresses small intestinal bacterial overgrowth (SIBO).

Cordyceps (Cordyceps militaris) (Link for cordyceps photo:
https://nicolesapothecary.com/products/cordyceps-mushroom-tincture)
Additionally, I use a cordyceps extract everyday to manage my MS. Similar to reishi, cordyceps has been used in Traditional Chinese Medicine for centuries. It is known to have neuroprotective properties that reduce neuronal cell death — an important consideration for those with MS. This unique mushroom is anti-inflammatory and helps to improve energy. It is also antimicrobial, antibacterial, antiviral, antifungal, and antiprotozoal, which is helpful for addressing poor gut health. Cordyceps is anti-cancer and regulates blood sugar as well.

Lastly, plantain, slippery elm, and marshmallow root calm inflammation, soothe mucous membranes, and create a protective layer that helps the gut to regenerate. I have found these botanicals to be essential for healing leaky gut.

If you would like to learn more about natural herbs and remedies, Dr. Nicole Apelian’s book, The Lost Book of Herbal Remedies: The Healing Power of Plant Medicine, is available here.
For access to Nicole’s Apothecary at a discounted rate, please use the coupon WELCOME10 at checkout for 10% off your first order. To learn how Nicole manages her MS on a daily basis, please read her detailed blog on this subject. Thank you!

Reishi is a vasodilator, so it is contraindicated for those with a bleeding disorder or for use before surgery. **Masé, G. (2012). Medicinal mushrooms: A brief history and overview of principal species. Retrieved on 08/27/2016 from http://www.vtherbcenter.org/wp-content/uploads/2012/04/Medicinal-Mushrooms.pdf

Please note that the contents of this article are for informational purposes only, do not constitute medical advice, and are not intended to be a substitute for diagnosis or treatment. Always seek the advice of a qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. In the event of a medical emergency, call a doctor or 911 immediately. Reliance on any information provided by this website is solely at your own risk.

Nicole Apelian, Ph.D.

Dr. Nicole Apelian is an herbalist, a mother, a survival skills instructor, an anthropologist, and a biologist. She has B.S and M.S. degrees in Biology from McGill University in Canada and the University of Oregon. She earned her Doctorate through Prescott
College while working as an anthropologist and ethnobotanist in Botswana.
She has spent years living in nature with the San Bushmen of the Kalahari Desert, one of the last indigenous peoples who still live as hunter-gatherers. Developing strong relationships within the tribe helped Nicole learn many of the remedies and skills she practices and teaches today and she continues her work with the San through her non-profit, “The Origins Project“.
An unexpected diagnosis of multiple sclerosis in 2000 led Nicole to apply her research skills towards her own personal wellness. She focused on a healthy living strategy, including deep nature connection and gratitude practices. Through changes in her lifestyle, recognizing profound mind-body linkages, and making and using her own remedies, Nicole went from bedridden to being fully alive and from surviving to thriving.
She believes that there are many more people suffering who need to find their own remedy. This became her life’s mission and the main reason for writing her book The Lost Book of Herbal Remedies: The Healing Power of Plant Medicine. In it she poured over 28 years of plant knowledge and her first-hand experiences of making her own poultices, tinctures, decoctions, salves, infused oils, and other herbal remedies.
In 2015 she was among the first women ever selected for the History Channel’s hit TV show “Alone”. Despite having MS, she went on to survive solo for 57 days straight in a remote area of Vancouver Island with little more than her hunting knife and the wild foods and medicines she found there.
For more about Dr. Nicole Apelian please visit https://nicoleapelian.com/. https://www.instagram.com/nicole_apelian/https://www.facebook.com/nicoleapeliansurvival/

 
References: 
Philip, A., & White, N. D. (2022). Gluten, Inflammation, and Neurodegeneration. American journal of lifestyle medicine, 16(1), 32–35. https://doi.org/10.1177/15598276211049345
Esmaeil Amini, M., Shomali, N., Bakhshi, A., Rezaei, S., Hemmatzadeh, M., Hosseinzadeh, R., Eslami, S., Babaie, F., Aslani, S., Torkamandi, S., & Mohammadi, H. (2020). Gut microbiome and multiple sclerosis: New insights and perspective. International immunopharmacology, 88, 107024. https://doi.org/10.1016/j.intimp.2020.107024
Jangi, S., Gandhi, R., Cox, L. et al. Alterations of the human gut microbiome in multiple sclerosis. Nat Commun 7, 12015 (2016). https://doi.org/10.1038/ncomms12015
Shahi, S. K., Freedman, S. N., Murra, A. C., Zarei, K., Sompallae, R., Gibson-Corley, K. N., Karandikar, N. J., Murray, J. A., & Mangalam, A. K. (2019). Prevotella histicola, A Human Gut Commensal, Is as Potent as COPAXONE® in an Animal Model of Multiple Sclerosis. Frontiers in immunology, 10, 462. https://doi.org/10.3389/fimmu.2019.00462

#diet #gutbacteria #gutbrainaxis #guthealth #gutmicrobiome #healthinnovation #microbiome #mindbody #naturopathichealth #nutrition #plantnutrition #spices #wellness
Which type of mushrooms do you regularly eat?

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Unprecedented Ai/ 3D mapping of brain and body

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Unprecedented Ai/ 3D mapping ...
Researchers from the Ludwig-Maximilians Universität München (LMU) and the LMU University Hospital developed a new method called wildDISCO that 3D maps the entire structures of the body using fluorescent markers, according to a July 10, 2023 article in Phys.org.

LMU scientists Dr. Ali Ertürk, Dr. Hongcheng Mai and Dr. Jie Luo mapped mouse body atlases, including the nervous system, protein expression, lymphatic vessels, blood vessels, and immune cells.

Ai integration enables details of complex biological systems. The team already discovered the integral role the gut microbiome plays in the development of the enteric nervous system.

The scientists believe it will reduce reliance on animal testing, while increasing efficiency of understanding diseases and developing new treatments.

https://phys.org/news/2023-07-wilddisco-visualizing-bodies-unprecedented.html

 

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薬用キノコ、自己免疫、および腸の健康: 真の治癒を発見した方法; Medicinal Mushrooms, Autoimmunity, & Gut Health: How I Discovered True Healing

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薬用キノコ、自己免疫、および腸... 薬用キノコ、自己免疫、および腸...
The following is part one by guest author Dr. Nicole Apelian. She was among the first women selected for the History Channel’s hit TV show “Alone”.

薬用キノコ、自己免疫、および腸の健康: 真の治癒を発見した方法
以下は、ゲスト著者のニコール アペリアン博士によるパート 1 です。彼女は、ヒスト リー チャンネルの人気テレビ番組「アローン」に選ばれた最初の女性であり、カナダ のマギル大学とオレゴン大学で生物学の学士号と修士号を取得しています。その後、プ レスコット大学で博士号を取得。

多発性硬化症の診断
30 代前半に多発性硬化症(MS)の診断を初めて受けた際、圧倒された気分で怖かった です。この病気が自分の健康に与える影響の速さを見るのは恐ろしいことでした。片目 が見えなくなり、バランスが崩れ、朝も起きられないほどの重度の疲労感に悩まされて いました。
しかし、それはほんの始まりでした。 病気が進行するに当たって、自分が好きな仕事をすることができなくなるし、日中は杖 が必要になり、夕方には車椅子が必要になり、かみそりのように鮮明だった私の記憶 は、絶え間ない脳の霧に置き換えられました。神経内科医の指示に従い、病気の進行を 遅らせ、症状を管理することを期待する為、薬の処方を開始しました.しかし、思った 通り自分の健康状態は良くならず、驚くべき速さで悪化し続けました。
このまま続けられない事をすぐに気づき、何かを変える必要があると思いました。健康 を取り戻して人生をやり直したいと思います。それで私は自分の健康を管理することに すると決めました。そして、自分の治癒の主な側面は、腸の健康を改善することでし た.
腸の健康と自己免疫の関係
自分の治癒の経験を通して、ある点が十分に明らかになりました。腸とマイクロバイオ
ームが損なわれている状態で、健康な心と体を持つことは不可能です。
これは、1腸の炎症とリーキーガットが自己免疫やうつ病や脳霧などに重要な要因であ
る事です。
1

2時間と妥協した腸は自己免疫や神経障害および炎症と関連していることが示されてい
ます。
3研究によると、多発性硬化症の人はマイクロバイオームが変化しており、腸内の細
菌、真菌、およびその他の微生物が健康な人とは異なります。
4いくつかの研究により、多発性硬化症と腸内環境異常の間に直接的な相関関係がある
ことが立証されています。面白いことに、多発性硬化症の患者はプレボテラ・ヒスティ
コーラという細菌のレベルが低い。これは、なぜマイクロバイオームの侵害が慢性炎症
を引き起こし、多発性硬化症が再発する傾向があるのかを説明できるかもしれない。

基礎的な治癒
腸の健康の重要性を発見してから、マイクロバイオームの腸内細菌叢異常症とリーキー
ガットの問題を治すことに取り組みました。もちろん食事療法がキーポイントです。丈
夫なマイクロバイオームと健康な腸をサポートするために、プレバイオティクス・プロ
バイオティクス・不溶性繊維・難消化性デンプンが豊富な食品を必ず食べるようにして
います。研究を通じて、葉物野菜は重要な栄養素と繊維が豊富に含まれているだけでな
く、炎症を軽減し腸管免疫を向上させるのに役立つ化合物である酪酸塩の生成を促進す
るため、特に重要であることがわかりました。
リーキーガットを治癒することも重要な考慮事項です。このますます一般的になってい
る健康障害は、不適切な食生活・寄生虫・憩室炎、または環境毒素への曝露によって発
症します。

有害な物質や微生物がリーキーガットの隙間を通って血流に入ると、全身に一連の炎症
が引き起こされ、自己免疫疾患の再発を引き起こし、他の健康問題を悪化させる可能性
があります。最適な健康状態が気になる場合は、リーキーガットへの対処が最優先事項
であることは誰も同意すると思います。

七面鳥の尾
The Takeaway
私が多発性硬化症の管理と腸の健康の促進のために、気に入る食生活はグルテンフリ
ー、抗炎症作用、そして多くの場合ケトジェニック作用です。炎症に対処するために、
断続的な絶食も実践しています。感謝の気持ちを持ったり、自然の中で過ごしたり、ヨ
ガをやったりすることでストレスに対処するのに役立っています。
2

重要なのは、リーキーガットを癒し、炎症を鎮め、ストレス反応を和らげ、エネルギー
を高め、認知機能を改善するため、私はこれらの特定の二重抽出霊芝・ライオンのたて
がみ・七面鳥の尾・冬虫夏草のキノコを毎日摂取していることです。そして腸全体の健
康をサポートするためにこれらの植物も使用しています。
この情報が、薬用キノコ、腸の健康、多発性硬化症の関係について役立の紹介になれば
甘いです。自己免疫や腸の健康障害に苦しんでいる人を知っている場合は、この投稿を
共有してください。
癒しの旅を頑張って下さい!
天然ハーブと治療法についてさらに詳しく知りたい場合は、ニコール・アペリアン博士 の著書『The Lost Book of Herbal Remedies: The Healing Power of Plant Medicine』をこちらで入手可能です。
Nicole’s Apothecary の割引料金を得るには、チェックアウトの時に WELCOME10 クー ポンを使用すれば、最初の注文は 10% オフになります。ニコールが日常的に多発性硬 化症をどのように管理しているかを学ぶために、この件に関する彼女の詳細なブログを 読んだ方が良いと思います。
 天然ハーブと治療法についてさらに詳しく知りたい場合は、ニコール・アペリアン博士
 の著書『The Lost Book of Herbal Remedies: The Healing Power of Plant
 Medicine』をここから入手できます。
 割引料金で購入するには、チェックアウト時にクーポン WELCOME10 を使用し、最初の 注文から 10% オフにしてください。ニコールが日常的に多発性硬化症をどのように管
 理しているかについては、彼女の詳細ブログをお読みください。 ありがとう!
 • 霊芝は血管拡張作用があるため、出血性疾患のある方や手術前の使用は禁忌で す。
 ** Mase G. (2012)。 薬用キノコ: 主要な種の簡単な歴史と概要。2016 年 8 月
27 日に http://www.vtherbcenter.org/wp-
  content/uploads/2012/04/Medicinal-Mushrooms.pdf
   より取得する。
 • この記事の内容は情報提供のみを目的とし、医学的アドバイスを構成するもので
 はなく、診断や治療の代替を意図したものではないことにご注意ください。病状
に関する質問がある場合は、必ず資格のある医療提供者のアドバイスを求めてく
 ださい。この Website を読んだことを理由にして、専門の医学的アドバイスを
 無視したり、アドバイスを求めるのを遅らせたりしないでください。医療上の緊
 急事態が発生した場合は、直ちに医師または 911 に電話してください。 この
 Website が提供する情報を信頼する場合は、お客様ご自身の責任で行ってくださ
い。
3

 • ニコール・アペリアン博士は、薬草医・母親・サバイバルスキルのインストラク
 ター・人類学者・生物学者です。彼女はカナダのマギル大学およびオレゴン大学
で生物学の学位を取得し、学士号と修士号を持っています。彼女はボツワナで人
類学者および民族植物学者として働きながらプレスコット大学で博士号を取得し
 ました。
 彼女は、今も狩猟採集民として暮らしている最後の先住民族のひとつであるカラ
 ハリ砂漠のサン・ブッシュマンたちと一緒に自然の中で何年も暮らしてきまし
た。
 部族内で強い関係を現像することで、ニコールは現在実践し教えている治療法や
 スキルの多くを学び、非営利団体「The Origins Project」を通じてサン族との
 活動を続けています。
 2000 年に多発性硬化症と予期せぬ診断を受け、ニコールは自分の研究スキルを
 自分自身の健康に応用することになりました。彼女は、深い自然とのつながりや
 感謝の習慣など、健康的な生活戦略に焦点を当てました。ライフスタイルを変
 え、心と体の深いつながりを認識し、独自の治療法を作成して使用することによ
 って、ニコールは寝たきりから完全に生き、生存から繁栄へと成長しました。
 彼女は、苦しんでいるたくさんの人々が自分自身の治療法を見つける必要がある
 と信じています。
 これが彼女の人生の使命となり、著書『The Lost Book of Herbal Remedies:
 The Healing Power of Plant Medicine』を執筆する主な理由となった。その中
 に彼女は 28 年以上にわたる植物の知識と、湿布・チンキ剤・煎じ薬・軟膏・注
 入油、その他のハーブ療法を自分で作った直接の経験を注ぎ込みました。
 2015 年、彼女はヒストリー チャンネルの人気テレビ番組「アローン」に史上初 めて選ばれた女性の一人でした。多発性硬化症を患っていたにも関わらず、彼女 は狩猟用ナイフとそこで見つけた野生の食べ物と薬だけを持って、バンクーバー
 島の人里離れた地域で 57 日間連続で一人で生き続けた。
 ニコール・アペリアン博士について詳しくは、こちらをご覧ください。
https://nicoleapelian.com/. https://www.instagram.com/ nicole_apelian/https://www.facebook.com/nicoleapelian survival/

Dr. Apelian has B.S and M.S. degrees in Biology from McGill University in Canada and the University of Oregon. She earned her Doctorate through Prescott College.

 
My Multiple Sclerosis Diagnosis


When I first received my multiple sclerosis (MS) diagnosis back in my early thirties, I was overwhelmed and scared. It was terrifying to watch the impacts of the disease rapidly deteriorate my health. I lost my eyesight in one eye, my balance was unstable, and I was experiencing crushing fatigue where it was difficult to even get out of bed in the morning.

But that was only the beginning.
As the disease progressed, I was unable to work at the job that I loved, needed a cane to walk during the day and a wheelchair in the evening, and my once razor-sharp memory was replaced with constant brain fog.
I followed my neurologist’s orders and began a regime of drugs in the hope it would slow the progression of the disease and manage symptoms. It didn’t. In fact, my health continued to worsen at an alarming rate.
I soon realized I couldn’t continue along this downward spiral — something needed to change. I wanted to regain my health and live life again. So I decided to take charge of my health. And a major aspect of my healing involved improving gut health.

The Link Between Gut Health and Autoimmunity

Throughout my journey of healing, one point has been made abundantly clear: If your gut and microbiome are impaired, it is impossible to have a healthy mind and body.

This is because intestinal inflammation and leaky gut are significant factors in autoimmunity, depression, and brain-fog.1
Time and again, a compromised gut has been shown to be associated with autoimmunity, neurologic disorders, and inflammation.2 Research has found that those with MS have an altered microbiome, where the bacteria, fungi, and other microorganisms in the gut are different from that of a healthy person.3

Several studies have established that there is a direct correlation between multiple sclerosis and gut dysbiosis. Interestingly, those with MS have lower levels of the bacteria Prevotella histicola, which may explain why a compromised microbiome creates chronic inflammation and a tendency towards MS flares.4

Foundational Healing

Once I discovered the importance of gut health, I set out to heal any issues with microbiome dysbiosis and leaky gut. Of course, diet is key. I make sure to eat foods that are rich in prebiotics, probiotics, insoluble fiber, and resistant starch to support a robust microbiome and healthy gut. Through my research I discovered that leafy greens are particularly important as they are not only packed with vital nutrients and fiber, but also encourage the formation of butyrate, which is a compound that helps to reduce inflammation and improve gut immunity.

Healing leaky gut is another important consideration. This increasingly common health disorder develops through poor diet, parasites, diverticulitis, or exposure to environmental toxins. When harmful substances or microbes are able to pass through the gaps of a leaky gut into the bloodstream, it creates a cascade of inflammation throughout the body, which can trigger an autoimmune flare and aggravate other health issues. I think we all can agree that addressing a leaky gut should be a top priority if you are concerned about optimal health.

The Takeaway

My favorite diet for managing multiple sclerosis and boosting gut health is gluten-free, anti-inflammatory, and many times ketogenic. To address inflammation I also practice intermittent fasting. Gratitude, spending time in nature, and yoga help me to manage stress. Importantly, I take these specific dual-extracted reishi, lion’s mane, turkey tail, and cordyceps mushrooms everyday to heal leaky gut, calm inflammation, soothe the stress response, boost energy, and improve cognitive function. And I use these botanicals to support overall gut health.


I hope this information has been a helpful introduction to the relationship between medicinal mushrooms, gut health, and multiple sclerosis. If you know of others who are struggling with autoimmunity or compromised gut health, please share this post.
All my best to you on your healing journey!

If you would like to learn more about natural herbs and remedies, Dr. Nicole Apelian’s book, The Lost Book of Herbal Remedies: The Healing Power of Plant Medicine, is available here.

For access to Nicole’s Apothecary at a discounted rate, please use the coupon WELCOME10 at checkout for 10% off your first order. To learn how Nicole manages her MS on a daily basis, please read her detailed blog on this subject. Thank you!

This is part one of a series by guest author Dr.Nicole Apelian. The second part of this series features mushrooms and herbs which are keys to maintaining a healthy gut.

Reishi is a vasodilator, so it is contraindicated for those with a bleeding disorder or for use before surgery. **Masé, G. (2012). Medicinal mushrooms: A brief history and overview of principal species. Retrieved on 08/27/2016 from http://www.vtherbcenter.org/wp-content/uploads/2012/04/Medicinal-Mushrooms.pdf
Please note that the contents of this article are for informational purposes only, do not constitute medical advice, and are not intended to be a substitute for diagnosis or treatment. Always seek the advice of a qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. In the event of a medical emergency, call a doctor or 911 immediately. Reliance on any information provided by this website is solely at your own risk.

Nicole Apelian, Ph.D.

Dr. Nicole Apelian is an herbalist, a mother, a survival skills instructor, an anthropologist, and a biologist. She has B.S and M.S. degrees in Biology from McGill University in Canada and the University of Oregon. She earned her Doctorate through Prescott
College while working as an anthropologist and ethnobotanist in Botswana.
She has spent years living in nature with the San Bushmen of the Kalahari Desert, one of the last indigenous peoples who still live as hunter-gatherers. Developing strong relationships within the tribe helped Nicole learn many of the remedies and skills she practices and teaches today and she continues her work with the San through her non-profit, “The Origins Project“.
An unexpected diagnosis of multiple sclerosis in 2000 led Nicole to apply her research skills towards her own personal wellness. She focused on a healthy living strategy, including deep nature connection and gratitude practices. Through changes in her lifestyle, recognizing profound mind-body linkages, and making and using her own remedies, Nicole went from bedridden to being fully alive and from surviving to thriving.
She believes that there are many more people suffering who need to find their own remedy. This became her life’s mission and the main reason for writing her book The Lost Book of Herbal Remedies: The Healing Power of Plant Medicine. In it she poured over 28 years of plant knowledge and her first-hand experiences of making her own poultices, tinctures, decoctions, salves, infused oils, and other herbal remedies.
In 2015 she was among the first women ever selected for the History Channel’s hit TV show “Alone”. Despite having MS, she went on to survive solo for 57 days straight in a remote area of Vancouver Island with little more than her hunting knife and the wild foods and medicines she found there.

For more about Dr. Nicole Apelian please visit https://nicoleapelian.com/. https://www.instagram.com/nicole_apelian/https://www.facebook.com/nicoleapeliansurvival/

References: 

Philip, A., & White, N. D. (2022). Gluten, Inflammation, and Neurodegeneration. American journal of lifestyle medicine, 16(1), 32–35. https://doi.org/10.1177/15598276211049345
Esmaeil Amini, M., Shomali, N., Bakhshi, A., Rezaei, S., Hemmatzadeh, M., Hosseinzadeh, R., Eslami, S., Babaie, F., Aslani, S., Torkamandi, S., & Mohammadi, H. (2020). Gut microbiome and multiple sclerosis: New insights and perspective. International immunopharmacology, 88, 107024. https://doi.org/10.1016/j.intimp.2020.107024
Jangi, S., Gandhi, R., Cox, L. et al. Alterations of the human gut microbiome in multiple sclerosis. Nat Commun 7, 12015 (2016). https://doi.org/10.1038/ncomms12015
Shahi, S. K., Freedman, S. N., Murra, A. C., Zarei, K., Sompallae, R., Gibson-Corley, K. N., Karandikar, N. J., Murray, J. A., & Mangalam, A. K. (2019). Prevotella histicola, A Human Gut Commensal, Is as Potent as COPAXONE® in an Animal Model of Multiple Sclerosis. Frontiers in immunology, 10, 462. https://doi.org/10.3389/fimmu.2019.00462

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Autism’s strongest link yet to gut microbiome

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Autism’s strong...
43 scientists of various disciplines found the strongest link yet between gut microbes, host immunity, genetic expression in the nervous system, and dietary patterns, according to a June 28 2023 Science Alert report.

The study shows a general gut profile that is consistently common among people with autism (ADS). For example, microbiologist Rob Knight from the University of California San Diego and his team found that gastrointestinal problems are a consistent indicator of autistic people.

According to the Science Alert report, researchers found 15 datasets including diet, metabolism, immune cells, and gene expression that point toward ADS. The authors found autism associated with particular gut microbes which matched those identified by a recent long-term study on fecal transplants among 18 children with ASD.

https://www.sciencealert.com/the-connection-between-autism-and-the-gut-microbiome-is-clearer-than-ever

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fecal transplants prove effective in strengthening gut and immune system

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fecal transplants prove effective...
Lindsey A. Edwards, PhD, from the Institute of Liver Studies, King’s College London, England, found that fecal microbiota transplants (FMT) can reset gut health, according to a June 23 2023 report by Medscape Medical News.

The pilot study showed that FMT strengthened the gut function and immune response, as well as ammonia metabolism in patients with cirrhosis.

Fecal transplants can improve gut health by modifying the gut microbiome and reducing ammonia levels in patients with cirrhosis.

“FMT offers a different way of beneficially modifying the microbiome that is safe for patients with chronic liver disease,” added co-investigator Debbie L. Shawcross, MD, also from King’s College London in the Medscape News report.

Another report by Medical News Today published February 13 2023 show gut microbe links to other immune symptoms such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Two studies found a lack of butyrate production in the gut, possibly caused by a deficiency of of the body’s main butyrate producingbacteria, Faecalibacterium prausnitzii. 

Edwards points out that fecal transplants have two key benefits when resetting a patient’s gut microbiome: it replaces potentially deadly bacteria and returns healthy beneficial bacteria to the patient.

https://www.medscape.com/viewarticle/993637

https://www.medicalnewstoday.com/articles/me-cfs-how-the-gut-microbiome-may-impact-the-immune-response

 

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By products of “plastics” can be fermented by our gut, study finds

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AD SPONSOR: MZinger Vending... AD SPONSOR: MZinger Vending is live in south Seattle. We serve food and drinks
with emphasis on your health and putting customers first. Call us at 206-200-2733; sales@mzinger.com.
By products of ...
The intake of compounds such as nanoparticles impacts our gut microbiota balance, changing gut composition everyday which in turn, influences our physiological process. A recent study shows that our gut microbiota is able to break down carbon nanomaterials into organic metabolites, according to a May 19 2023 Phys.org report. What is the result of this fermentation process? The short answer is “short chain fatty acids” (SCFAs).

Prof. Chen Chunying from the National Center for Nanoscience and Technology (NCNST) of the Chinese Academy of Sciences (CAS) showed that gut microbiota can ferment carbon nanomaterials (CNMs) as carbon sources into SCFAs.

Specifically, researchers found in mice studies a “variety of microbial enzymes, including hexokinase, pyruvate kinase, pyruvate dehydrogenase and butyrate kinase” which were involved in fermenting CNMs into butyrate.

It is a serendipitous discovery, given that gut microbes can ferment synthetics previously perceived as potentially harmful into something potentially useful to our bodies. However, a Cambridge report based on a number of European studies cautions that “effects on NPs agglomeration and aggregation are still unknown”.

https://phys.org/news/2023-05-reveals-gut-microbiota-ferment-carbon.pdf

https://www.cambridge.org/core/journals/gut-microbiome/article/intake-of-nanoparticles-and-impact-on-gut-microbiota-in-vitro-and-animal-models-available-for-testing/BAECA0F1AA93D5806648F06A2254B183#

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gut microbiome drives neutrophil count

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gut microbiome drives neutroph...
Hokkaido University’s Faculty of Medicine have shown how our gut microbiome drives a process known as granulopoiesis that replenishes neutrophil counts. Neutrophils are a type of white blood cell that helps the body fight infection. They tested changes in the blood of mice following treatments such as hematopoietic, stem cell transplants (SCT) or chemotherapy, according to Genetic Engineering and Biotechnology News (November 22, 2022 issue). The mechanism was found to depend on T cell production of IL-17. Low neutrophil counts in the blood or neutropenia happens in leukemia patients, stem cell transplantation or following chemotherapy.

Research was led by Hokkaido University’s Associate Professor Daigo Hashimoto, PhD, and Professor Takanori Teshima, PhD. The potential clinically relevance of this finding can lead to “rapid recovery of neutrophils after SCT and chemotherapy”, says Dr. Hashimoto in Genentech News.

https://www.genengnews.com/news/gut-microbiome-drives-production-of-neutrophils-after-prolonged-chemotherapy/

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preventing pre-cancerous polyps from forming

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preventing pre-cancerous poly...
A new study published in Cell Host & Microb by Massachusetts General Brigham has linked certain types of gut bacteria to the development of precancerous colon polyps, as stated by a May 31 2023 Medical Express report.

The new study shows we “have an opportunity to intervene and prevent colorectal cancer from forming.” said co-corresponding author Daniel C. Chung, MD, medical co-director of the Center for Cancer Risk Assessment at the Mass General Cancer Center and a faculty member of the Gastroenterology Division. Colorectal cancer is America’s second leading cause of cancer-related deaths.

Medical Express adds that risk factors for colorectal cancer and polyps influences the bacteria that live in our intestines through lifestyle factors like being overweight or obese, low physical activity levels, a diet high in red and processed meats, smoking, and alcohol use.

The researchers took data from 1,200 people getting routine screening colonoscopies and gathering information about their lifestyle habits, as well as stool samples.

https://medicalxpress.com/news/2023-05-gut-microbiome-linked-precancerous-colon.amp

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