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“WHERE THINGS SO SMALL CAN HAVE A MASSIVE IMPACT ON YOUR HEALTH.”
Herbsprout is a webblog and podcast dedicated to sharing the health benefits of herbs, food, innovations related to our gut microbiome. Herbsprout seeks to bridge the vast chasm dividing the mainstream medical community and alternative medicine.

healthy butyrate can be produced from almonds

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healthy butyrate can be produc...
A clinical study led by Kings College London Professor of Dietetics Kevin Whelan investigated how gut microbes break down almonds to produce butyrate, a specific microbiota product associated with several health benefits.

This new research found that consuming almonds significantly increases butyrate, a type of beneficial short-chain fatty acid (SCFA) produced by microbes in the colon when they digest fiber. Butyrate is the primary fuel source for colonocytes, the cells that line the colon, according to the study funded by the Almond Board of California. 87 healthy adults participated in this 4-week study.

Results from the study showed significant differences in stool frequency as well as significant increases in butyrate in the colon. Other measured outcomes from the study included relative abundance of fecal bifidobacteria, fecal microbiota composition and diversity, fecal SCFAs, whole-gut transit time, gut pH, stool output (both frequency and consistency), and gut symptoms.

https://www.prnewswire.com/news-releases/almond-consumption-may-benefit-some-gut-microbiota-functionality-study-finds-301651443.html?tc=eml_cleartime

For further information on the study, contact Megan Brodsky, #206-697-9212, or Megan.brodsky@porternovelli.com.
#colon #guthealth #gutmicrobiome #nutrition #wellness

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More on gut microbiome influences on depression

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image source: dreamstime image source: dreamstime
The influence of genetic variation on the rate of depression ranges from 37% to 48%, showing a strong relation between family history and depression. The gut microbiome can be a promising approach for managing depression.

Gut dysbiosis is associated with major depressive disorder (MDD) by involvement with various aspects of Gut-brain axis (GBA). It promotes neuroinflammation and causes behaviour alteration, according to the September 07, 2022 Science Direct report.

There are three diet metabolites - kynurenine, tryptophan, and propionic acid - that greatly influence the activities of the gut microbiome and the deficiencies of which can contribute to depression. Researchers found that depression disorder also shows gut-brain dysregulation, an increase in inflammatory cytokines in the blood of depressive patients, dysregulation in fatty acid metabolism, neuropeptide, gut hormone and neurotransmitter synthesis, and abnormal immune system activation, as reported by Science Direct.

https://www.sciencedirect.com/science/article/abs/pii/S0166432822003497
#alternativemedicine #depression #guthealth #gutmicrobiome #healthinnovation #microbiome #mindbody

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Looking for specific microbes helps identify cancer; aids in early treatments

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image source: dreamstime.com image source: dreamstime.com
Subhajyoti De, associate professor of cancer systems biology at Rutgers Cancer Institute of New Jersey together with RWJBarnabas Health, found that microorganisms may be new targets for earlier diagnosis or treatment of pancreatic cancer (1).

According to the October 10 2022 Rutgers University press release, they were able to identify tumor-associated microbes and measure the activity of the host cells at the same time. They examined the microbiome of pancreatic tumors and identified particular microorganisms that are associated with inflammation and poor survival (2).

Short of two weeks earlier, research by Lian Narunsky Haziza, a cancer biologist at the Weizmann Institute of Science in Israel, found that tumors contain millions of microbes and fungi, representing dozens of species, according to a September 29 2022 New York Times article (2).

So-called tumor microbiome is proving so distinctive in each type of cancer that some scientists hope to find early signs of hidden tumors by measuring the microbial DNA they shed into the blood, says the study led by Dr. Haziza.

1) https://www.rutgers.edu/news/microorganisms-tumors-may-help-identify-new-approaches-treating-pancreatic-cancer

2) https://www.nytimes.com/2022/09/29/science/cancer-tumors-fungi-bacteria-microbiome.html
#bacteria #cancercells #guthealth #gutmicrobiome #healthinnovation #microbiome #tumor

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Healthy stool from fecal transplant in an IBS patient's digestive track reduces symptoms

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source: dreamstime source: dreamstime
Stool with healthy microorganisms inserted into a person’s digestive tract has been shown to reduce abdominal stress and tiredness in patients with irritable bowel syndrome (IBS), according to a September 13, 2022 article in Everyday Health.

The efficacy of this inexpensive treatment has shown to last three years for over 90% of patients, and beyond three years for over 70% of patients, according to the report by author Magdy El-Salhy, MD, a gastroenterologist at Stord Helse Fonna Hospital in Norway. Her team found that dysbiosis, a gut micriobiome imbalance, was lower among those receiving active treatment after two to three years.

https://www.everydayhealth.com/ibs/fecal-transplant-provides-relief-from-irritable-bowel-syndrome-symptoms/
#dysbiosis #guthealth #gutmicrobiome #ibs

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Cayenne pepper helps to diversify microbiome community

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source: dreamstime.com source: dreamstime.com
On April 19 2022 Mind Body Green reported a study that found "that capsaicin (in cayenne pepper) alters the gut microbial community structure by increasing the diversity of the community." Capsaicin is an antioxidant said to aid in proper digestion, with anti-inflammatory effects. Researchers used the in vitro model to conduct their research.

Capsaicin stimulates the nerves in your stomach and us said to help to increase the production of digestive fluid. According to WebMD, it sends enzymes to the stomach to aid in digestion, and protectshe the stomach from infections.

https://amp.mindbodygreen.com/articles/capsaicin-gut-health-study
#bacteria #datascience #gutmicrobiome #health #healthinnovation #wellness

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What antibiotics disturb our gut microbiome

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source: dreamstime.com source: dreamstime.com
Antibiotics are used to fight pathogens but also target commensal bacteria, disturbing the composition of gut microbiota and causing dysbiosis and disease.

According to an October 13 2021 Medical Express report, antibiotics are known to cause asthma, food allergies, obesity, gastrointestinal problems and Clostridioides difficile infections.

The October 13 2021 article in Nature said 144 antibiotics were studied to assess their affect on 38 human gut microbiome species. The study found that two common antibiotics macrolides and tetracyclines, inhibited nearly all gut bacteria tested, but also killed several species.

https://medicalxpress.com/news/2021-10-tackling-collateral-antibiotics.html

https://www.nature.com/articles/s41586-021-03986-2

https://doi.org/10.1038/s41586-021-03986-2
#antibiotics #guthealth #gutmicrobiome #medicine #wellness

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Sugar diets are not healthy especially for IBD patients; 砂糖食は特に炎症性腸疾患IBDの患者にとっては健康的ではありません

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Sugar diets are...
On October 28 2020 Inverse reported the impact of sugar consumption in mice led by co-author, Hasan Zaki, a researcher at the University of Texas Southwestern Medical Center. He and his team studied the effects of different types of sugars on gut microbiome by testing inflammatory responses on gut microbiota in mice.

They tested the impact of glucose, sucrose, and fructose on inflammatory bowel diseases (IBD) such as Crohn’s disease and ulcerative colitis. The mice were fed high levels of these sugars for one to five weeks.

Mice that were given these high sugar diets suffered from aggressive colon inflammation with severe diarrhea and a rapid loss of nearly 20 percent of their body weight. The sugar was fed to a particular gut bacteria called Akkermansia muciniphila, known to degrade mucus in the gut lining.

Researchers also transferred the gut microbiota of sugar-fed mice into healthy mice. The result also exacerbated healthy mice, who received the gut microbiota transferred from the sugar fed mice.

JAPANESE:
2020年10月28日、共著者に指導でテキサス大学南西医療センターの研究者のHasan Zakiがマウスの砂糖消費の影響について報告しました。
彼が自分のチームと共に、マウスの腸内細菌叢に対する炎症反応をテストすることにより、腸内細菌叢に対するさまざまな種類の糖の影響を研究しました。

彼らは、クローン病や潰瘍性大腸炎などの炎症性腸疾患(IBD)に対するグルコース、ショ糖、果糖の影響をテストしました。マウスに糖を高レベルで1〜5週間与えました。

高糖食を与えられたマウスは、重度の下痢を伴う攻撃的な結腸の炎症と体重のほぼ20パーセントの急速な減少でした。砂糖は、粘液を腸のライニングに劣化することで知られているアッカーマンシア・ムシニフィラと呼ばれる特定の腸内細菌に給餌されました。

研究者はまた、砂糖を与えられたマウスの腸内細菌叢を健康なマウスに移しました。結果はまた、砂糖を与えられたマウスから移された腸内細菌叢を受け取った健康なマウスを悪化させました。


https://www.inverse.com/mind-body/how-does-sugar-influence-the-microbiome/amp

See the following articles on IBD for additional information:

https://en.bloguru.com/healthtech/382125/changing-dynamics-of-gut-microbiome-in

https://en.bloguru.com/healthtech/362224/diet-and-mindfulness-therapy-can-help
#IBD #ai #bacteria #cardiovasculardisease #datascience #gutmicrobiome #health #healthinnovation #healthtech #obesity #wellness

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Microbiome Health Chart, October 2020 (click on chart to ZOOM IN)

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CLICK ON CHART TO ZOOM IN. CLICK ON CHART TO ZOOM IN. CLICK ON CHART TO ZOOM IN. CLICK ON CHART TO ZOOM IN. CLICK ON CHART TO ZOOM IN. CLICK ON CHART TO ZOOM IN. CLICK ON CHART TO ZOOM IN. CLICK ON CHART TO ZOOM IN.
This chart shows connections between our gut microbiome and various ailments or diseases, and offers food, herbal remedies, or supplements which may give relief to those ailments by positively impacting the microbiome.
This is not medical advice, so consult your doctor before making any health related decisions. Copyright (C) Herbsprout.com/ MobileZinger LLC.
#ai #artificialintelligence #bacteria #datascience #diet #gutmicrobiome #health #healthinnovation #healthtech #herbalmedicine #herbs #machinelearning #mindbody #plantnutrition #spices

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2 short chain fatty acids in the gut tied to breast cancer treatment efficacy

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October is Breast Cancer Awa... October is Breast Cancer Awareness Month; source: depositphotos.com
Just as we have reported last week about how the presence of butyrate supports a healthy gut, on the other hand, it can be detrimental to breast cancer chemotherapy. According to a September 17 2020 report in the American Journal of Managed Care (AJMC), 2 short chain fatty acids (SCFAs), propionate and butyrate, have been identified as tied to the efficacy of breast cancer chemotherapy (1). The study was conducted in Scotland led by Kirsty Ross, MBChB, MSc, a specialist registrar in medical oncology at the Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom. The Beatson West Cancer Centre studied 21 patients with early-stage breast cancer.

The SCFAs were shown to be lower in the gut bacteria of patients achieving pathological complete response (pCR) compared with those not achieving pCR after surgery. According to Ross and her colleagues, they "dampen down the immune system’s ability to target cancer cells", as quoted in the AJMC article (1).

This points back to the fact that when it comes to personal health, it is very personal, and what is healthy for one person is not necessarily healthy for another person. As Herbsprout article quoted Viome CEO Naveen Jain, "one man's food is another man's poison." (2)

1. https://www.ajmc.com/view/gut-microbiota-may-influence-pcr-in-early-stage-breast-cancer

2. https://en.bloguru.com/healthtech/373232/one-mans-food-is-another-mans-poison
#ai #bacteria #breastcancer #cancer #cardiovasculardisease #datascience #gutmicrobiome #health #healthinnovation #healthtech #obesity

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The health benefits of butter

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The health benefits of butter
One common misconception is that butter is not healthy for you because it is fattening. It is true. It is fattening, but in a good way; it contains good fat. Butter is a good source of healthy fat, omega-3 fatty acids, particularly unsaturated, organic butter. It is the best, richest dietary source of a short chain fatty acid (SCFA) called butyrate.

The microbiome in our gut are known to metabolize acetate, propionate, and butyrate (at 60%, 25%, and 15% respectively), according to Dr. Deanna Minich (1). Butyrate is rich source of energy for the cells in our gut.

Butyrate is the energy source for cells that line the wall of our gut and helps prevent diarrhea and other digestive health issues. Beyond that, it plays a key role as an anti-inflammatory, gene regulation, and maintaining a balanced immune system.

In addition to butyrate, Butter is an excellent source of vitamin A, Vitamin E, and another fat called conjugated linoleic acid (CLA), which is also known to be an anti-inflammatory and provide immune support (2).

1. https://www.deannaminich.com/the-benefits-of-butter-a-rich-source-of-butyrate/

2. https://www.healthline.com/nutrition/is-butter-bad-for-you#cla
#ai #bacteria #cardiovasculardisease #datascience #gutmicrobiome #health #healthinnovation #healthtech #obesity

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