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HerbSprout Microbiome Blog -

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“WHERE THINGS SO SMALL CAN HAVE A MASSIVE IMPACT ON YOUR HEALTH.”
Herbsprout is a webblog and podcast dedicated to sharing the health benefits of herbs, food, innovations related to our gut microbiome. Herbsprout seeks to bridge the vast chasm dividing the mainstream medical community, alternative medicine, and Asian medicine, especially of China (TCM), India (Ayurveda), and Japan (eJim & Kampo).

phenolic compounds in food aid in reducing free radicals; TCM dismissed by WebMD

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phenolic compounds in food aid...
According to a mice study and other studies reported in Handawi on November 08 2021, phenolic compounds effectively reduced oxidative stress from the buildup of free radicals. Free radicals are known to lead to various diseases including cardiovascular diseases, diabetes, cancer, and neurodegenerative diseases (1).

Phenolic compounds have received considerable attention for their antioxidant, anti-inflammatory, and anti-carcinogenic properties. Two main compounds mentioned here are protocatechuic acid (PCA) and protocatechuic aldehyde (PAL).

Phenolic compounds are naturally present in many plant-based foods such as fruits, vegetables, beans, spices, rice, crops, legumes, hemp, and lentils. Herbs such as basil, lemon thyme, and mint also contain high concentrations of these anti-oxidant compounds.

Salvia miltiorrhiza, also known as red sage, Chinese sage, danshen, is a perennial plant in the genus Salvia, commonly used in traditional Chinese medicine. While Danshen possesses high concentrations of PCA and PAL, WebMD warns that eating too much of it and for some people, it can cause upset stomach. On the other hand, WebMD fails to sight any scientific evidence or research it’s claims about Danshen while acknowledging that the same therapeutic compounds in other western foods are effective (2).

According to the Handawi article, the effectiveness of distributing these antioxidants to the body and brain depends in part on the gut microbiome ability to biotransform them into lower molecular weight compounds (1).

1. https://www.hindawi.com/journals/ecam/2021/6139308/

2. https://www.webmd.com/vitamins/ai/ingredientmono-931/danshen

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tastes for bitter veggies influenced by oral microbes

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source: depositphotos.com source: depositphotos.com
According to a November 02 2021 report by Ars Technica, oral microbiome in human saliva can affect odor detection, which may be linked to individual tastes for or against certain bitter chemicals in our food.

According to the report, about 25 percent of people can't taste propylthiouracil (PROP), a chemical that is similar to the bitter compounds found in cabbage, cauliflower, broccoli, coffee, tonic water, and dark beers. This means 75% of people detect unpleasant bitterness in these vegetables and beverages.

The bitter compounds in these foods are called glucosinolates. There are about 25 “bitterness genes”, according to scientists, which are also responsible for much of the nutritional value of these foods. Beyond the genetics, some people take kindly to certain types of bitterness and not others, matters of personal preferences.

https://apple.news/ADD2K-b7DRnSUh-Gz1WCVHg

https://pubs.acs.org/doi/abs/10.1021/acs.jafc.1c03889

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What antibiotics disturb our gut microbiome

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source: dreamstime.com source: dreamstime.com
Antibiotics are used to fight pathogens but also target commensal bacteria, disturbing the composition of gut microbiota and causing dysbiosis and disease.

According to an October 13 2021 Medical Express report, antibiotics are known to cause asthma, food allergies, obesity, gastrointestinal problems and Clostridioides difficile infections.

The October 13 2021 article in Nature said 144 antibiotics were studied to assess their affect on 38 human gut microbiome species. The study found that two common antibiotics macrolides and tetracyclines, inhibited nearly all gut bacteria tested, but also killed several species.

https://medicalxpress.com/news/2021-10-tackling-collateral-antibiotics.html

https://www.nature.com/articles/s41586-021-03986-2

https://doi.org/10.1038/s41586-021-03986-2
#antibiotics #guthealth #gutmicrobiome #medicine #wellness

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Rhubarb and Phellodendron bark Keys to anti inflammatory herbal medicine

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source: Dreamstime.com source: Dreamstime.com
Rhubarb, Scutellaria root, Phellodendron bark, and Coptidis rhizome are commonly used to make “San Huang Powder.” Study by researchers determined that this herb extract was proved to be antibacterial and anti inflammatory, according to an October 12 2021 report in Hindawi.com.

The in-vitro assay showed that Rhubarb and Phellodendron bark extracts decreased the levels of inflammatory cytokines, IL-8, and GM-CSF on LPS-induced HMEC-1 cells. These two herbs are key ingredients in traditional Chinese medicine “San Huang Powder” used to treat burns.

https://www.hindawi.com/journals/ecam/2021/2900060/

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Gut microbiome health may affect muscle growth

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The researchers found that for muscles to grow following exercise, according to new a September 27, 2021 article In Medical Express written by The Physiological Society. Based on a study of mice, the gut microbiome may be important for the health of our muscles.

The study found that the mice that received antibiotic treatment which killed the bacteria of their gut microbiome showed significantly less muscle growth than mice who did not receive the antibiotic treatment.

John McCarthy, senior author added “world-class runners were found to have more of a particular type of bacteria that provided an additional source of energy which was thought to help them run faster. Thus, the gut microbiome makes substances that appear to be important for skeletal muscles,” he is quoted saying in the Medical Express report.

https://medicalxpress.com/news/2021-09-microbiome-muscle-growth-loss-conditions.html

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Coral Microbiome key to climate change survival

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The microbiome of corals -- which comprise bacteria, fungi and viruses -- play an important role in the ability of corals to tolerate rising ocean temperatures, according to a September 30 2021 article in Science Daily led by Penn State University. Says Penn State biology professor Monica Medina, prolonged exposure to heat can cause 'bleaching' and the animal to die.

Viridiana Avila-Magaña, former student at Penn State, and team tracked genes that have already diverged in expression across species in response to any given stimuli -- in our case heat stress. She is currently a postdoctoral fellow at Colorado University Boulder.

The entire holobiont -- the coral animal, photosymbiont and microbiome -- is involved in the stress response. They found several genes that aid a coral’s response to heat stress. They also found more tolerant species had greater bacterial activity and diversity, according to Science Daily. The microbiome includes bacteria, fungi and viruses.

Among the three coral species examined - mountainous star coral, the knobby brain coral, and the starlet coral - the starlet coral was found to be more heat stress tolerant. This is due in part to a higher number and diversity of thermally tolerant microbes in their microbiomes, according to the Science Daily article.

https://www.sciencedaily.com/releases/2021/09/210930082401.htm

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Bifidobacteria in yogurt may help gut micriobiome says report

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source: dreamstime.com source: dreamstime.com
According to a September 22 2021 article in Healio, Bifidobacterium animalis subsp. lactis BB-12 in yogurt may protect patients against harmful changes in the gut microbiome as first reported in Nutrients.

“ If one picks a well proven probiotic, they can expect to see important changes such as short chain fatty acid and microbiome protection,” Daniel Merenstein, MD, from the department of family medicine, Georgetown University Medical Center, told Healio Gastroenterology. Dr. Merenstein based this on a 7 - day study of 42 patients, measuring “fecal levels of short-chain fatty acid and bacterial composition”.

https://www.healio.com/news/gastroenterology/20210922/probioticcontaining-yogurt-may-protect-against-gut-microbiome-changes-linked-to-antibiotics

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Some species of gut bacteria support, others resist weight loss

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In a September 16 2021 Science Focus report, Seattle’s Institute for Systems Biology lead author Dr Christian Diener is quoted saying “your gut microbiome can help or cause resistance to weight loss and this opens up the possibility to try to alter the gut microbiome to impact weight loss.”

Dr. Diener’s assertions are based on a study of 5,000 dieters with a focus of 105 individuals and a control group, collecting blood and stool samples from the participants, and studying their genetic material. The study found that specific gut bacteria in each group were resistant, while others supported weight loss. In the Science Focus article, Dr. Diener concludes that “the gut microbiome is a major player in modulating whether a weight loss intervention will have success or not.”

https://www.sciencefocus.com/news/gut-microbiome-weight-loss-study/amp/



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Study of common medicine on gut bacteria shows reduced efficacy

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source: depositphotos.com source: depositphotos.com
Common medications can accumulate in gut bacteria, says a new study reported September 08 2021 in Medical Express. Research on the subject was conducted by Medical Research Council (MRC) Toxicology Unit at the University of Cambridge and the European Molecular Biology Laboratory (EMBL) in Germany. The building up of drugs in our gut bacteria can alter bacterial function and reduce the drug’s effectiveness.

15 common drugs were combined and tested with 25 different gut bacteria to see how they interacted. The researchers found that the drug accumulated in the gut bacteria demonstrated some signs of reduction in the availability of the drug to the rest of the human body. It is believed that the accumulation altered bacterial function, believed to be linked to side-effects. The research was first reported in Nature.

https://medicalxpress.com/news/2021-09-common-medications-accumulate-gut-bacteria.amp

https://www.genengnews.com/news/microbiomes-metabolism-altered-by-bioaccumulation-of-medications/

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Global Microbiome Market reached nearly $5 billion in 2020

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source: Dreamtime.com source: Dreamtime.com
According to a July 12, 2021 Market and Research report, the global microbiome market reached a value of nearly $4,977.2 million in 2020, having increasing at a compound annual growth rate (CAGR) of 12.6% since 2015. The market is expected to grow at a CAGR of 12.7% from 2020 to reach $9,061.0 million in 2025.

The human microbiome market is segmented by type into microbial drugs and fecal microbiota transplantation (FMT) with microbial drugs accounting for 70% of the total. Asia-Pacific was the largest region in the global microbiome market, accounting for 37.2% share of the total in 2020, according to Market and Research.

The global microbiome market is expected to reach $15,554.8 million in 2030, at a CAGR of 11.4%.

https://www.prnewswire.com/news-releases/global-microbiome-markets-report-2021-market-is-expected-to-reach-15-55-billion-in-2030--at-a-cagr-of-11-4-301326835.html

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