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“Live Long and Prosper” with ketones & polyphenols

Sep

3

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Distinguished doctor and medical researcher Dr. Steve Gundry says polyphenols aid in everything from heart health to gut health and weight loss. Why? Based on his research, Dr. Gundry discovered these polyhenols facilitate caloric bypass, enabling the mitochondria in our body to ignore excessive amounts of food, and bypass converting them into stored fats (1).

More than 8,000 polyphenols are out there, and they are divided into four main categories: flavonoids, stilbenes, lignans, and phenolic acids, according to a May 24, 2022 Wellandgood.com article (2).

Ketones created by our liver are even more effective than the polyphenol foods, in fact the most effective at signaling caloric bypass, but helps all your cells work better, according to the National Institute of Aging.

Dr. Gundry discovered medium chain triglycerides (MCT) naturally found in certain foods, can never be converted to fats and can only be converted to ketones. Both Columbia and McGill Universities confirmed studies that individuals who consume increasing amounts ketones showed significant decreases in body fat and weight. He found that communities that consume large amounts of — goat cheese sheeps milk, acacia, and coconut oil — each of which are among the largest sources of MCTs, are also among the longest living communities in the world (1).

Top sources of MCTs are coconut and coconut products - coconut oil, coconut butter and full fat coconut milk; palm kernel oil; and in lesser amounts- butter, milk, yogurt and cheese 3).

Top sources of polyphenols include Herbs and Spices such as ginger and turmeric, Cocoa, and berries such as blackberries, blueberries, and strawberries (2).

1) https://fb.watch/feicm0Zfwq/

2) https://www.wellandgood.com/polyphenols/#main-content

3) https://www.healthline.com/nutrition/mct-oil-101

Gut bacteria that regulates cholesterol

Aug

24

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A subset of bacteria called Bacteroides help to regulate cholesterol levels in the blood by producing cholesterol sulfate, according to postdoctoral researchers Henry Le and Ming-Ting Lee at the College of Agriculture and Life Sciences, co-first authors of the study (1).

Though more study is needed, early clues reveal cholesterol sulfate acts as a signaling molecule for a slew of biological pathways, according to a study published August 18 in Nature Microbiology and reported by Phys.org (1).

National Institute of Health says cholesterol sulfate is metabolized in different pathways. While it’s function of remains an enigma, cholesterol sulfate has emerged as a regulatory molecule, and serves an important stabilizing role (2).

1) https://phys.org/news/2022-08-gut-bacteria-cholesterol.amp

2) https://pubmed.ncbi.nlm.nih.gov/12730293/

Microbe found to generate electricity

Aug

10

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A sediment organism Geobacter sulfurreducens, first found along the Potomac River, has been discovered to generate an electrical charge, according to a February 2020 article in BigThink.

The microbe a member of the Geobacter genus, a group known as “electrigens” for their known ability to generate an electrical charge. “It was UMass Amherst microbiologist Derek Lovley who found and wrote about the microbe in the late 80s,” according to Big Think.

He found that the microbe produces electrically conductive protein nanowires, and his lab recently developed a new Geobacter strain that could produce them more rapidly and inexpensively. Lovely worked together with electrical engineer Jun Yao, also of UMass Amherst, to create a device they call “ air-gen”, creating “electricity out of thin air.” The Air-gen generates clean energy 24/7. “It’s the most amazing and exciting application of protein nanowires yet,” he’s quoted saying in BigThink.

https://bigthink.com/the-present/air-gen/

Stool Bank for fecal transplant?

Jul

21

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Fecal transplants don’t work from one person to another. But what about transplants of your younger self?

Researchers at Harvard Medical School and Brigham and Women’s Hospital claim it’s a good idea for people to bank their stool samples when they’re young and healthy to rejuvenate their gut microbiome, according to a June 30 2022 article in The Scientist (1). Dr. Scott Weiss and Yang-Yu Liu propose this stool bank for fecal transplant(s) for use later in life.

As scientists discover the importance of personalized medicine as the most effective approach to addressing a person’s individually unique health care needs, these researchers and others believe the key to its efficacy lies in a person’s past.

Already, a company in Singapore is thinking along the same lines. Cord life is the first company to work with the Asian Microbiome Library in Singapore to collect “precision” databank of stool samples (2).

1) https://www.the-scientist.com/news-opinion/banking-previous-poos-could-a-transplant-of-feces-from-your-past-heal-you-70180

2) https://thehomeground.asia/destinations/singapore/faecal-attraction-first-southeast-asia-poo-bank-set-up-in-singapore/

Lactobacillus helps reduce depression

Jun

30

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A study found that an increase consumption of bacteria called Lactobacillus shows a 15% reduction in showing symptoms of depression. the gut flora of the participants who received the probiotic, according to a study by Dr. Graham Rook, emeritus professor of medical microbiology with the University College London.

https://www.medicalnewstoday.com/articles/probiotics-could-good-gut-bacteria-help-tackle-depression#Study-limitations-and-next-steps

Nuts about walnuts? It’s a good thing

Jun

15

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Did you notice walnuts look like the brain? That’s because they’re good for the brain and not because they have the physical characteristics of a human brain but because they have the most omega-3 fatty acids of all the nuts, according to Facty.

But that’s not it. Walnuts have more good fatty acids, for heart health such as monounsaturated fatty acids. Walnuts contain healthy fatty acids like oleic acid and linoleic acid which can aide in reducing bad LDL cholesterol and increasing good HDL (high density lipoproteins) cholesterol; “the good cholesterol “ which removes harmful LDL cholesterol, as explained by Webmd (2).

https://facty.com/food/nutrition/the-delicious-health-benefits-of-walnuts/

2. https://www.webmd.com/cholesterol-management/guide/hdl-cholesterol-the-good-cholesterol

Human microbiome market to become $1.37 billion by 2029

Jun

1

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Taking a break from science, what about the economics of our gut microbiome? According to a Digital Journal article reporting on MarketsandMarkets™, the global human microbiome market is projected to reach USD 1.37 billion by 2029 from USD 269 million in 2023, at a CAGR of 31.1% from 2023 to 2029.

The report says the growth is largely due to growth in gut microbiome treatment and drug development. Digital Journal reports that the Asia Pacific region is the fastest-growing region of human microbiome research spending market from 2023 to 2029.

https://www.digitaljournal.com/pr/human-microbiome-market-worth-1370-million-by-2029-global-trends-share-and-leading-key-players

Download PDF Brochure: https://www.marketsandmarkets.com/pdfdownloadNew.asp?id=37621904

Our gut microbiome contributes to cravings

May

26

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According to an April 26 2022 Medical News Today report, microbes contribute to our cravings and play a major role in our processing of nutrients.

These are based on mice studies by Dr. Kevin Kohl, assistant professor in the Department of Biology at the Kenneth P. Dietrich School of Arts and Sciences at the University of Pittsburgh and Dr. Trevelline, Rose postdoctoral fellow at the Cornell Lab of Ornithology.

Dr. Trevelline said the microbes in the gut were beneficial contributors to a lot of processes, particularly by synthesizing the nutrients humans need and supplementing our diets.

Their research showed that the mice that received diverse types of microbiota voluntarily changed their diet preferences. “Our work shows that animals with different compositions of gut microbes choose different kinds of diets,” Dr. Kohl said.

Drs. Trevelline and Kohl also discovered that that varying levels of tryptophan in mice’s blood led to their choosing different diets, according to the Medical News Today article.

MIT develops bacteria that breaks down antibiotics

May

12

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MIT News reported April 11 2022 that MIT researchers successfully engineered a bacteria based antibiotic treatment. The enzyme of this bacteria can help reduce the risk of inflammation caused by antibiotics.

MIT engineers developed a strain of bacteria that is safe for human consumption that safely produces an enzyme that breaks down a class of antibiotics called beta-lactams. These include ampicillin, amoxicillin, and other commonly used drugs, according to the MIT News article.

James Collins, the Termeer Professor of Medical Engineering and Science in MIT’s Institute for Medical Engineering and Science (IMES) and Department of Biological Engineering, and the senior author of the new study, refers to this application as “living biotherapeutics”.

https://news.mit.edu/2022/bacteria-good-gut-microbes-antibiotics-0411

Researchers near replicating carbon reduction process in nature

May

2

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Researchers found that enzymes from certain bacteria in the soil turns carbon dioxide in the air into carbon molecules, a process that helps reduce the carbon footprint which drives climate change.

An international consortium of university researchers including Stanford’s Department of Energy’s SLAC National Accelerator Laboratory have figured out a way to potentially artificially duplicate the process in lab, according to an April 29 2022 report by Glennda Chui of the Stanford National Accelerator Lab.

The process known as carbon fixing, is the key component in photosynthesis. But instead of a 20 times slower process in plants, the soil bacteria, Kitasatospora setae, relies on enzymes called Rubisco. Researchers also found it can also produce antibiotics, according to Chui’s article quoting Soichi Wakatsuki, a professor at SLAC and Stanford.

The next step will be to build on an enhanced version of the artificial process.

https://www6.slac.stanford.edu/news/2022-04-29-how-soil-microbe-could-rev-artificial-photosynthesis.aspx