Nacalai USA's Blog

Separation of amyloid β fragment peptides with racemised and isomerised aspartic acid residues using an original chiral resolution labeling reagent

Feb

8

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We are pleased to announce that the study using our DL-amino acid labeling kit, made in collaboration with Professor Hideaki Kakeya from Graduate School of Pharmaceutical Sciences, Kyoto University, was selected for inclusion in HOT Articles 2023 by the Royal Society of Chemistry journal Analyst, 2023, Advance Article

The following products were used in this study.
DL-Amino Acid Labeling Kit

Reference: Separation of long-stranded RNAs by RP-HPLC

Jan

26

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We published "Separation of long-stranded RNAs by RP-HPLC using an octadecyl-based column with super-wide pores" in Analytical Sciences. 2022.

DOI: https://doi.org/10.1007/s44211-022-00253-w


The following products were used in this study.

COSMOSIL RNA-RP1 Packed Column:
https://www.nacalaiusa.com/products/view/408/mrna-and-oligonucleotides-purification-with-chromatography

ASMS 2023: Booth# 418

Dec

8

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We are attending the ASMS 2023 Annual Conference, booth No. 418. June 4-8, Houston. TX
https://www.asms.org/

PITTCON 2023: Booth# 2744

Dec

8

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We will be attending the PITTCON 2023, booth No. 2744, March 20-22, Philadelphia, Pennsylvania.
https://pittcon.org/pittcon-2023/

Reference: Separation of nicotinamide metabolites

Aug

22

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We published " Separation of nicotinamide metabolites using a PBr column packed with pentabromobenzyl group modified silica gel" in Analytical Biochemistry. 2022, 655, 114837..

https://doi.org/10.1016/j.ab.2022.114837


The following products were used in this study.

COSMOSIL PBr Packed Column:
https://www.nacalaiusa.com/products/view/238/cosmosil-pbr

Comparison of biphenyl and other aromatic stationary phases

Aug

11

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Many of our columns feature aromatic ring-based stationary phases with strong π-π interactions, notably our πNAP (naphthylethyl) and PYE (pyrenylethyl) columns. Several other companies produce similar columns using a biphenyl phase, which has become a popular alternative to C18 in recent years. Here, we compare these columns for several kinds of analysis.

https://www.nacalaiusa.com/products/view/558/application-comparison-of-biphenyl-and-other-aromatic-stationary-phases

The following columns were used in this application.

COSMOSIL piNAP:
https://www.nacalaiusa.com/products/view/107/cosmosil-pi-nap

COSMOSIL PYE:
https://www.nacalaiusa.com/products/view/59/cosmosil-pye-and-cosmosil-npe

Application: delta-9 Tetrahydrocannabinol (Δ9 THC) Enantiomers

Jul

7

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One of our customers has succeeded in separating delta-9-THC enantiomers using our CHiRAL 5A column.
https://www.nacalaiusa.com/products/view/355/cosmosil-chiral-series
https://www.nacalaiusa.com/products/view/407/application-cannabinoids-analysis

Cannabinoids of various types have recently become compounds of interest with the potential to treat various ailments. As many of these compounds have optical isomers, separation these enantiomers could prove to be important to research into their therapeutic potential.

COSMOSIL® Application（HPLC / UHPLC / SFC）

Apr

21

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COSMOSIL Application, which includes more than 7,900 applications using COSMOSIL columns, is now available. The application is searchable by sample category, sample name, CAS RN., column name and particle size.

*** Only show new applications added since September 2021
https://www.nacalai.co.jp/cosmosil/data/csmosrchlst.cfm?UpdDate=20210930000000&NameKey=&NameSrch=2&CASNo=&RyuKei=0&AppNo=&kensu=20&lc=E

*** Only show applications using SFC columns
https://www.nacalai.co.jp/cosmosil/data/csmosrchlst.cfm?SFC_Check=SFC&NameKey=&NameSrch=2&CASNo=&RyuKei=0&AppNo=&kensu=20&lc=E

New application data for isomers of 13-hydroxy-octadecadienoic acid

Apr

20

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These compounds have been found to be related to several diseases, including atherosclerosis, asthma, and several types of cancer. As the risk of disease is related to the ratio of the cis/trans isomers, the ability to separate them chromatographically is important.

Please click the link below to find more information:
https://www.nacalaiusa.com/uploads/13-hydroxy-octadecadienoate-methyl-ester.png
https://www.nacalaiusa.com/products/view/61/cosmosil-cholester

Reference: New amino-acid labeling reagent, (D)FDLDA

Apr

6

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"Separation and identification of the DL-forms of short-chain peptides using a new chiral resolution labeling reagent" was published in Anal Bioanal Chem on 06 April 2022.
https://doi.org/10.1007/s00216-022-04048-w


The following products were used in this study.

*** DL-Amino Acid Labeling Kit ***
https://www.nacalaiusa.com/products/view/528/dl-amino-acid-labeling-kit

*** COSMOCORE 2.6C18 packed column ***
https://www.nacalaiusa.com/products/view/235/cosmocore-2-6c-sub-18-sub

*** COSMOCORE 2.6Cholester packed column***
https://www.nacalaiusa.com/products/view/254/cosmocore-2-6cholester

*** COSMOSIL 3PBr packed column ***
https://www.nacalaiusa.com/products/view/238/cosmosil-pbr

*** COSMOSIL CHiRAL 3C packed column ***
https://www.nacalaiusa.com/products/list/71/chiral-separation-columns