Skin, our body's largest organ shows bidirectional relationship between gut and skin

As pointed out by a January 2020 article by Amy Myers MD, "your skin is the largest organ in your body, your first defense against the outside world." Since we know that 70 to 80% of your immune system is located in your gut, there must be a connection between the gut and skin, right? Researchers in fact have found such connections. Dr. Myers begins backing this assertion by saying that our gut's 300 to 500 species defend our body against pathogens as do the healthy bacteria covering our skin. Both our gut and skin need to be covered in beneficial bacteria when in a healthy state (see https://www.amymyersmd.com/2019/02/gut-skin-connection/ ).

Researchers found evidence that Dr. Myers assertions are in fact true. They demonstrate an intimate, bidirectional connection between the gut and skin, gastrointestinal (GI) health to skin, according to an NIH report.

This includes microbiome’s contribution to three common skin disorders – acne, atopic dermatitis (AD), and psoriasis, and probiotic supplementation as a therapeutic remedies.

The study found that short chain fatty acids (SCFAs), products of dietary fibers fermented by components of the gut microbiome, demonstrate a protective role against the development of inflammatory disorders including arthritis and allergies.

"SCFAs resulting from fiber fermentation in the gut – propionate, acetate, and butyrate – are believed to play a pivotal role in determining the predominance of certain skin microbiomic profiles." Propionibacterium, for example, is a genus capable of producing SCFAs, predominantly acetate and propionic acid are one of a number of gut microbes that influence our immune defense system.

Another study found that lactobacillus brevis in rats resulted in decreased cutaneous arterial sympathetic nerve. (Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048199/ ).

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Skin, our body's largest organ shows bidirectional relationship between gut and skin

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