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“WHERE THINGS SO SMALL CAN HAVE A MASSIVE IMPACT ON YOUR HEALTH.”
Herbsprout is a webblog and podcast dedicated to sharing the health benefits of herbs, food, innovations related to our gut microbiome. Herbsprout seeks to bridge the vast chasm dividing the mainstream medical community and alternative medicine.

Ginseng & Ginger are two healthy TCMs during stressful times

May
30
thread
Source: getty images Source: getty images Ginseng & Ginger are tw...
A May 17 2020 article by Yahoo News suggests you might consider incorporating some traditional Chinese medicine (TCM) ideas into your daily practice. There's much to choose from- qi gong, acupressure/ acupuncture, teas and tonics, and food. Yahoo News recommended these TCM remedies in this order.

Given that food and teas are more prevalent and widely used, let's look at it from the opposite order. Beginning with the universally accepted herb ginger, which contains Gingerol. Regular consumption of it couldn't hurt. Gingerol is the main bioactive compound in ginger that is anti-inflammatory and a digestive aid. This is based on studies referenced by the Healthline article below.

Ginseng has also been tested and proven to boost the immune system with its bioactive compounds, ginsenosides and gintonin, according to WebMD. Regarding both ginger and ginseng, there have been broad but varying unproven claims that these food based herbs provide other benefits such as lowering blood sugar and treating cancer. However, consuming them in moderation can help and is recommended.

For more information see: https://news.yahoo.com/amphtml/try-traditional-chinese-medicine-practices-214001491.html ; and
https://www.healthline.com/nutrition/ginseng-benefits#section1
#ai #bacteria #datascience #diet #gutmicrobiome #health #healthinnovation #healthtech #herbalmedicine #herbs #mentalhealth #plantnutrition #probiotics #psychobiotics

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Holobiome & Viome - "Microbiomes Intimate Role in Every Human Disease”

May
9
thread
In a May 07, 2020 Science Magazine article, Holobiome announced it seeks to produce new treatments for depression and other disorders of the brain and nervous system beginning with isolating and culturing bacteria to benefit humans through our gut microbiome. The focus of the startup will be psychobiotics, those that address brain - related ailments, says company CEO, Phil Strandwitz. It seems the creation of startups like these are a sign of the times.

In an early interview by Herbsprout writer Chris Kenji Beer, Viome's CEO Naveen Jain takes us into a deeper understanding of the role of microbiomes to our health. “Every single chronic disease that we know of -- from Parkinson’s, Alzheimer’s, autism, depression, anxiety, obesity, autoimmune diseases, cancer-- every single one of these diseases have one thing in common, chronic inflammation. Every one of them is caused by microbiome. Think about this. Every one of these diseases is caused by microbiomes. And every time we take antibiotics we are killing those microbiomes.”
“A lot of people are saying ‘I know about microbiomes, what is so unique about it?’ The change is we not only know what is inside our gut, we are able to know exactly what they are doing.”

THE RNA - TRANSCRIPTOME TESTING

How do we know? “The latest wave (of Microbiome testing) is transcriptome. The transcriptome testing approach looks at the RNA and analyzes what the RNA of microbiomes are doing. The popular ‘16S sequencing’ of microbiomes testing is a twenty year old technology and is not able to do this.”
“What if you can find out exactly what is going on (inside the RNA of microbiomes)? What if you know what vitamins they are producing? What if you knew which specific compounds they are producing that cause inflammation? And from this data, what if you were able to figure out which specific content and combinations of food can actually address these inflammations more effectively than any prescription drugs we have available today?” asserts Jain.

Given the lag in treatments particularly for mental health treatments, Holobiome proposes to source and find microbe -based solutions to these ailments, or "psychobiotics". What if Holobiome and Viome are at the beginning of a new trend in health care where startups like Holobiome are among hundreds of companies focused on finding and deploying microbe- based solutions, gut bacteria treatments for different human diseases?

See article on Holobiome, https://www.sciencemag.org/news/2020/05/meet-psychobiome-gut-bacteria-may-alter-how-you-think-feel-and-act ; and Viome http://Viome.com .
#ai #bacteria #datascience #diet #gutmicrobiome #health #healthinnovation #healthtech #herbalmedicine #herbs #mentalhealth #plantnutrition #probiotics #psychobiotics

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Gut bacteria strains found to prevent onset of Parkinson's

Apr
12
thread
Gut bacteria strains found to p...
Parkinson’s News Today reported on April 08, 2020 that several strains of a bacteria Bacillus subtilis "inhibits, delays, and reverses" the buildup of the protein alpha-synuclein in Parkinson’s disease patients. The study, “Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans,” was originally published in the journal Cell Reports. The building up of the protein alpha-synuclein, or Lewy bodies, is known to create the degeneration of brain cells in Parkinson’s disease (see source: https://parkinsonsnewstoday.com/2020/04/10/probiotic-strain-of-b-subtilis-halts-alpha-synuclein-aggregation-in-round-worms/ ).

Last September. Herbsprout reported that scientists found evidence that Parkinson's disease may originate in the gut. Building on that discovery, scientists found the strains of gut microbes that may prevent Parkinson's, each finding building on the next.

It is not yet conclusive whether or not the a-synuclein build up occurs first in our gut, and before or after it reaches the brain. This study was tested in round worms, and is proven as a preventive measure. It is not able to treat Parkinson's disease but prevent it's growth. While further studies are required , it poses the possibility of a preventive dietary supplement, according to scientists involved in this study (see article https://www.cell.com/cell-reports/home).

Other articles by Herbsprout include microbial treatments for Parkinson's, https://en.bloguru.com/healthtech/360989/microbial-treatments-for-parkinsons ; and Parkinson's disease may originate in the gut, https://en.bloguru.com/healthtech/357162/parkinsons-may-originate-in-the-gut .
#ai #bacteria #datascience #diet #gutmicrobiome #health #healthinnovation #healthtech #herbalmedicine #herbs #mentalhealth #plantnutrition #probiotics #psychobiotics

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Links between gut health and mania/ bi-polar disorder

Feb
16
thread
Links between gut health and ...
A September 04, 2019 article in the New Scientist suggests that eating a proper amount of psychobiotics, a derivation of probiotics, can improve one's mental health. (see
https://www.newscientist.com/article/mg24332460-500-how-what-you-eat-directly-influences-your-mental-health/ ). Probiotics may help improve a variety of mental health conditions, in part due to an anti-inflammatory effect, including those suffering from manic depression and bi-polar (BP) disorders. Psychobiotics are believed to mitigate chemical imbalance in the brain, and offer an alternative to drug treatment, claims the article.

Lithium has become the most accepted remedy used for treating BP. Studies such as the 2020 Neuropsychobiology report have found little connection between lithium intake and Escherichia coli or Lactobacillus rhamnosus, except that it appears to support a stronger richness and diversity of these species. However, they found a noticeable increase in Clostridium, Peptoclostridium, Intestinibacter, and Christenellaceae following lithium treatment (see https://www.karger.com/Article/FullText/504496 ). These results suggest a connection between our gut microbiota and BP treatment using lithium.

SAMPLE HUMAN TRIALS:

Researchers from Johns Hopkins University School of Medicine did a study to determine if probiotics could help recently discharged manic patients, according to a Harvard Health Publishing blog of June 25, 2018. Two groups of 33 patients were given Lactobacillus and Bifidobacterium species to one group and a placebo to the second group over a 24 week period.

The results for the rates of rehospitalization were 51.1% in the placebo group and 24.2% in the group who took probiotics. On average, the reduction in readmission was 74% lower in the probiotic group, and a 90% reduction of hospitalization in the group with the highest inflammation score. Additionally, patients who took probiotics and were rehospitalized stayed in the hospital on average 2.8 days, compared with 8.3 days for those taking placebo.

A Nature article in February 2019 referenced human trials that found connections between coprococcus and dialister bacteria, with lower levels contributing to mental health issues and specifically depression (see article, https://www.nature.com/articles/s41564-018-0337-x ).

While tests on mice are less reliable than human trials, they can effectively make connections between similar human functions. For example, The Scientist article reported that study coauthor Julio Licinio, a psychiatrist at SUNY Upstate Medical University in Syracuse made fecal transplants of schizophrenic mice that verified lower glutamate, glutamine, and GABA in their hippocampi. These are key amino acid neurotransmitters that are essential for brain function (see https://www.the-scientist.com/news-opinion/gut-microbes-may-play-a-role-in-mental-health-disorders-66039/amp ).

What scientists can say with some accuracy is that there is a link between our gut bacteria and mental health. One step further, they've identified specific species of bacteria, keystone species such as bifidobacteria and lesser known species such as coprococcus and dialister bacteria. The next steps will be to prove efficacy and FDA approval as a form of treatment in mental health patients. When this might be achieved is still to be determined, but scientists are getting closer.
#ai #bacteria #datascience #diet #gutmicrobiome #health #healthinnovation #healthtech #herbalmedicine #herbs #mentalhealth #plantnutrition #probiotics #psychobiotics #spices

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