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“WHERE THINGS SO SMALL CAN HAVE A MASSIVE IMPACT ON YOUR HEALTH.”
Herbsprout is a webblog and podcast dedicated to sharing the health benefits of herbs, food, innovations related to our gut microbiome. Herbsprout seeks to bridge the vast chasm dividing the mainstream medical community and alternative medicine.

Study: gut bacteria to reduce allergies

Oct
7
thread
Study: gut bacteria to reduce a...
A September 14 2020 Genetic Literacy Project reported various findings that point to a potential gut microbiome solution to allergies. Researchers have spent decades on this concept called oral immunotherapy, which has come into use as a treatment for food allergies. Allergies affect an estimated 32 million people in the United States, including about two schoolchildren per classroom.

In March, scientists discovered large amounts of antibodies against peanut allergens in the stomach and gut of allergic patients, according to the Genetic Literacy Project article. Dr. Cathryn Nagler, immunologist at the University of Chicago, discovered the allergic mice lacked the normal communication that takes place between gut microbes and immune cells. Honing in on the specific gut bacteria strains, her team found that Clostridia, but not Bacteroides, prevented food-allergic responses.

Another study led by Rima Rachid and Talal Chatila at Boston Children’s Hospital, found that the single species Subdoligranulum variabile and a set of Clostridia species, including Anaerostipes caccae, prevented allergic responses. In both studies regulatory T cells were key to the response with the microbes triggering the response. Researchers found that by adding healthy microbes to allergic mice showed results in preventing the allergic reactions in those mice.

https://geneticliteracyproject.org/2020/09/14/do-you-have-food-allergies-manipulating-the-gut-microbiome-might-treat-them/

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Fungi linked to cognitive impairment can be aided by keto diet

Oct
3
thread
Fungi linked to cognitive impai...
According to an August 2020 NeuroScience article, scientists say the keto diet has an unique ability to help regulate fungi living with the gut bacteria of patients with mild cognitive impairment (MCI). The principal investigator of this research Hariom Yadav is assistant professor of molecular medicine at Wake Forest School of Medicine, of Wake Forest Baptist Health.

Yadav and his team tested the rRNA TS1 gene in 11 individuals, 6 with MCI issues, to see how the Mediterranean ketogenic diet and American Heart Association diet influences the patients' cognitive functions, specifically "Alzheimer’s markers in cerebrospinal fluid and gut bacteria".

While Dr. Yadav said more research needed to be done to determine more specifics, he said this study shows that there is a connection between the keto diet in reducing harmful fungi in the gut which has been associated with Alzheimer’s symptoms.

https://neurosciencenews.com/alzheimers-gut-fungi-keto-diet-16939/amp/

For further reading on the subject, see https://journals.sagepub.com/doi/10.1177/0300060520925930

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Microbiome Health Chart, October 2020 (click on chart to ZOOM IN)

Sep
30
thread
CLICK ON CHART TO ZOOM IN. CLICK ON CHART TO ZOOM IN. CLICK ON CHART TO ZOOM IN. CLICK ON CHART TO ZOOM IN. CLICK ON CHART TO ZOOM IN. CLICK ON CHART TO ZOOM IN. CLICK ON CHART TO ZOOM IN. CLICK ON CHART TO ZOOM IN.
This chart shows connections between our gut microbiome and various ailments or diseases, and offers food, herbal remedies, or supplements which may give relief to those ailments by positively impacting the microbiome.
This is not medical advice, so consult your doctor before making any health related decisions. Copyright (C) Herbsprout.com/ MobileZinger LLC.
#ai #artificialintelligence #bacteria #datascience #diet #gutmicrobiome #health #healthinnovation #healthtech #herbalmedicine #herbs #machinelearning #mindbody #plantnutrition #spices

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2 short chain fatty acids in the gut tied to breast cancer treatment efficacy

Sep
26
thread
October is Breast Cancer Awa... October is Breast Cancer Awareness Month; source: depositphotos.com
Just as we have reported last week about how the presence of butyrate supports a healthy gut, on the other hand, it can be detrimental to breast cancer chemotherapy. According to a September 17 2020 report in the American Journal of Managed Care (AJMC), 2 short chain fatty acids (SCFAs), propionate and butyrate, have been identified as tied to the efficacy of breast cancer chemotherapy (1). The study was conducted in Scotland led by Kirsty Ross, MBChB, MSc, a specialist registrar in medical oncology at the Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom. The Beatson West Cancer Centre studied 21 patients with early-stage breast cancer.

The SCFAs were shown to be lower in the gut bacteria of patients achieving pathological complete response (pCR) compared with those not achieving pCR after surgery. According to Ross and her colleagues, they "dampen down the immune system’s ability to target cancer cells", as quoted in the AJMC article (1).

This points back to the fact that when it comes to personal health, it is very personal, and what is healthy for one person is not necessarily healthy for another person. As Herbsprout article quoted Viome CEO Naveen Jain, "one man's food is another man's poison." (2)

1. https://www.ajmc.com/view/gut-microbiota-may-influence-pcr-in-early-stage-breast-cancer

2. https://en.bloguru.com/healthtech/373232/one-mans-food-is-another-mans-poison
#ai #bacteria #breastcancer #cancer #cardiovasculardisease #datascience #gutmicrobiome #health #healthinnovation #healthtech #obesity

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Topically applying a probiotic to skin improves eczema

Sep
23
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Topically applying a probiotic t...
A September 09 2020 Medical Express article reported that experimental probiotic skin therapy using strains of live Roseomonas mucosa bacteria was isolated, grown, then applied to children with eczema. The application resulted in long term (up to 8 months) of relief from eczema symptoms. Roseomonas mucosa is a bacteria that naturally lives on the skin (1).

In the study of 20 children suffering from eczema, researchers found that topically applying Roseomonas mucosa bacteria to the skin showed a 50% improvement in 17 of the 20 recipients. The test results were also confirmed to reduce inflammation and symptoms of eczema and atopic dermatitis through tests of 10 adults, and 5 children (2).

1. https://medicalxpress.com/news/2020-09-probiotic-skin-therapy-eczema-children.amp

2. https://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.aaz8631

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The health benefits of butter

Sep
19
thread
The health benefits of butter
One common misconception is that butter is not healthy for you because it is fattening. It is true. It is fattening, but in a good way; it contains good fat. Butter is a good source of healthy fat, omega-3 fatty acids, particularly unsaturated, organic butter. It is the best, richest dietary source of a short chain fatty acid (SCFA) called butyrate.

The microbiome in our gut are known to metabolize acetate, propionate, and butyrate (at 60%, 25%, and 15% respectively), according to Dr. Deanna Minich (1). Butyrate is rich source of energy for the cells in our gut.

Butyrate is the energy source for cells that line the wall of our gut and helps prevent diarrhea and other digestive health issues. Beyond that, it plays a key role as an anti-inflammatory, gene regulation, and maintaining a balanced immune system.

In addition to butyrate, Butter is an excellent source of vitamin A, Vitamin E, and another fat called conjugated linoleic acid (CLA), which is also known to be an anti-inflammatory and provide immune support (2).

1. https://www.deannaminich.com/the-benefits-of-butter-a-rich-source-of-butyrate/

2. https://www.healthline.com/nutrition/is-butter-bad-for-you#cla
#ai #bacteria #cardiovasculardisease #datascience #gutmicrobiome #health #healthinnovation #healthtech #obesity

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Covid 19 virus lingers in the gut after recovering

Sep
16
thread
Covid 19 virus lingers in the g...
A September 07 2020 article in Bloomberg said the coronavirus may remain in the gut for some time after clearing the respiratory system, according to Chinese University of Hong Kong researchers. They claim the coronavirus may continue to infect and replicate in the digestive tract.

Primarily spread through droplets in the air, a February 2020 study of 73 hospitalized coronavirus patients in Guangdong province, China found more than half tested positive for the virus in their stool. Fecal presence of coronavirus was found present in patients six days after testing negative of the virus.

This leads to the possibility that understanding the the presence of certain strains of bacteria in coronavirus patients could aid in the development of a microbiome- based remedy for treating the Coronavirus. They particularly showed a loss of protective microbes and a proliferation of disease-causing ones.

The Chinese University is offering free screening stool tests to travelers arriving at the airport since late March, and identified six infected children among more than 2,000 samples tested, accordingto the Bloomberg report.

https://www.bloomberg.com/amp/news/articles/2020-09-07/covid-19-patients-may-have-prolonged-gut-infection-study-finds

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New discovery about how bacteria adheres to our gut's cell walls

Sep
12
thread
New discovery about how bact...
Researchers at the University of Basel and ETH Zurich have found a new mechanism by which bacteria adhere to cellulose fibers on the cell walls of the human gut, according to an August 28 2020 article in Phys.Org.

The significance of understanding this is it helps us understand an important part of how our gut microbiome influences our health. Professor Michael Nash from the University of Basel and ETH Zurich studied combinations of "single-molecule atomic force microscopy, single-molecule fluorescence and molecular dynamics simulations", according to the report.

Researchers believe there is a dual binding mode, one significantly stronger than the other. The bacteria is believed to control the binding mode preference by modifying the proteins and the adherence strength. "This would allow switching from a low to high adhesion state depending on the environment," according to Nash. Learning this process and how it works may help scientists employ bacteria that adhere to certain disease targets, at the higher adhesion rate.

https://phys.org/news/2020-08-bacteria-adhere-fiber-gut.amp
#ai #bacteria #datascience #gutmicrobiome #health #healthinnovation #healthtech #longevity #microbiome #nutrition #wellness

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Gut microbiome influences sleep patterns

Sep
9
thread
Gut microbiome influences slee...
Reseachers at University of Illinois at Chicago, conducted a rat study linking "disturbed sleep patterns, elevated blood pressure, and disruptions to the gut microbiome", according to a September 03 2020 New Atlas article. When studying the sleep patterns of rats, researchers found that abnormal sleep patterns developed increase in blood pressure. While this has been confirmed in previous human studies, new information about the gut microbiome was revealed in this study.

The study led by researcher Katherine Maki discovered an increase in the gut bacteria associated with inflammation. Theoretically,
Reseachers at University of Illinois at Chicago, conducted a rat study linking "disturbed sleep patterns, elevated blood pressure, and disruptions to the gut microbiome", according to a September 03 2020 New Atlas article. When studying the sleep patterns of rats, researchers found that abnormal sleep patterns developed increase in blood pressure. While this has been confirmed in previous human studies, new information about the gut microbiome was revealed in this study.

The study led by researcher Katherine Maki discovered an increase in the gut bacteria associated with inflammation. Theoretically, this suggests that probiotics could be a useful remedy in the future to address high blood pressure and hypertension.

https://newatlas.com/science/poor-sleep-high-blood-pressure-bacteria-gut-microbiome-hypertension/

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Gut Bacteria’s role in cholesterol

Sep
5
thread
Gut Bacteria’s ...
According to an August 12 2020 article in Cell.com, the ismA genes in certain microbial strains can help reduce cholesterol levels in mice (1).

A study published in the journal of the Society of Applied Microbiology found that Lactobacillus plantarum TAR4 reduced cholesterol levels by as much as 48%. Lactic acid bacteria strains were isolated and examined for "acid tolerance, bile salt resistance and hypocholesterolemic properties," according to the mice study (2).

Sarahs-world.blog, the Asian dish Tapai, which is fermented cassava or rice, contains a special Lactobacilli strain that has probiotic effects in rats and can break down cholesterol as well (3).

The article states bacterium under investigation uses a network of "scaffold proteins and enzymes on the outer cell wall, referred to as a cellulosome network, to attach to and degrade cellulose fibers. These cellulosome networks are held together by families of interacting proteins."

It demonstrates that probiotic Lactobacillus plantarum TAR4 supplements can reduce bile acids and reduce cholesterol levels.

1. https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(20)30295-X?_returnURL

2. https://sfamjournals.onlinelibrary.wiley.com/doi/full/10.1111/jam.14678

3. https://sarahs-world.blog/bacteria-reduce-cholesterol/

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